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Open AccessAnemone bleaching impacts the larval recruitment success of an anemone-associated fish
In marine environments, mutualisms such as those between corals or sea anemones and their algal symbionts (Symbiodiniaceae) play a key role for supporting surrounding biodiversity. However, as the breakdown of...
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Article
Open AccessA novel nuclear receptor subfamily enlightens the origin of heterodimerization
Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding or dimerizatio...
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Article
Open AccessVariation on a theme: pigmentation variants and mutants of anemonefish
Pigmentation patterning systems are of great interest to understand how changes in developmental mechanisms can lead to a wide variety of patterns. These patterns are often conspicuous, but their origins remai...
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Article
Open AccessAnemonefish, a model for Eco-Evo-Devo
Anemonefish, are a group of about 30 species of damselfish (Pomacentridae) that have long aroused the interest of coral reef fish ecologists. Combining a series of original biological traits and practical feat...
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Article
Open AccessAnthropogenic stressors impact fish sensory development and survival via thyroid disruption
Larval metamorphosis and recruitment represent critical life-history transitions for most teleost fishes. While the detrimental effects of anthropogenic stressors on the behavior and survival of recruiting fis...
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Open AccessSea anemone and clownfish microbiota diversity and variation during the initial steps of symbiosis
Clownfishes and sea anemones form an intriguing long-term association, but the mechanism underlying this symbiosis is not well understood. Since clownfishes seem to cover themselves with sea anemone mucus, we ...
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Article
The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death
Ectodysplasin receptor EDAR is seen as a typical Tumor Necrosis Factor receptor (TNFR) family member known to interact with its ligand Eda-A1, and signaling mainly through the nuclear factor-kappaB (NF-κB) and...
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Article
Open AccessAmphioxus functional genomics and the origins of vertebrate gene regulation
Vertebrates have greatly elaborated the basic chordate body plan and evolved highly distinctive genomes that have been sculpted by two whole-genome duplications. Here we sequence the genome of the Mediterranea...
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Open AccessOntogenetic and phylogenetic simplification during white stripe evolution in clownfishes
Biologists have long been fascinated by the striking diversity of complex color patterns in tropical reef fishes. However, the origins and evolution of this diversity are still poorly understood. Disentangling...
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Article
Complete and rapid reversal of the body color pattern in juveniles of the convict surgeonfish Acanthurus triostegus at Moorea Island (French Polynesia)
Color polymorphism is widespread in animals and can be associated with temporary adjustments to environmental variables (phenotypic plasticity). In teleost fishes, one of the most remarkable examples of color ...
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Article
Open AccessLineage-specific duplication of amphioxus retinoic acid degrading enzymes (CYP26) resulted in sub-functionalization of patterning and homeostatic roles
During embryogenesis, tight regulation of retinoic acid (RA) availability is fundamental for normal development. In parallel to RA synthesis, a negative feedback loop controlled by RA catabolizing enzymes of t...
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Article
Open AccessTinkering signaling pathways by gain and loss of protein isoforms: the case of the EDA pathway regulator EDARADD
Only a handful of signaling pathways are major actors of development and responsible for both the conservation and the diversification of animal morphologies. To explain this twofold nature, gene duplication a...
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Article
Open AccessEvolution of retinoic acid receptors in chordates: insights from three lamprey species, Lampetra fluviatilis, Petromyzon marinus, and Lethenteron japonicum
Retinoic acid (RA) signaling controls many developmental processes in chordates, from early axis specification to late organogenesis. The functions of RA are chiefly mediated by a subfamily of nuclear hormone ...
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Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling
Retinoic acid (RA) is a vitamin A-derived morphogen controlling important developmental processes in vertebrates, and more generally in chordates, including axial patterning and tissue formation and differenti...
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Article
Open AccessEvolution of bilaterian central nervous systems: a single origin?
The question of whether the ancestral bilaterian had a central nervous system (CNS) or a diffuse ectodermal nervous system has been hotly debated. Considerable evidence supports the theory that a CNS evolved j...
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Article
Open AccessMolecular adaptation and resilience of the insect’s nuclear receptor USP
The maintenance of biological systems requires plasticity and robustness. The function of the ecdysone receptor, a heterodimer composed of the nuclear receptors ECR (NR1H1) and USP (NR2B4), was maintained in i...
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Article
Open AccessBisphenol A induces otolith malformations during vertebrate embryogenesis
The plastic monomer and plasticizer bisphenol A (BPA), used for manufacturing polycarbonate plastic and epoxy resins, is produced at over 2.5 million metric tons per year. Concerns have been raised that BPA ac...
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Erratum to: From carrot to clinic: an overview of the retinoic acid signaling pathway
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Article
From carrot to clinic: an overview of the retinoic acid signaling pathway
Vitamin A is essential for the formation and maintenance of many body tissues. It is also important for embryonic growth and development and can act as a teratogen at critical periods of development. Retinoic ...
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What does Evolution Teach us about Nuclear Receptors?
In this chapter we first summarise the current knowledge about the phylogenetic spectrum of nuclear receptors (NRs). Then, we discuss how studying their diversity can be helpful to make insights about their ev...