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  1. Article

    Open Access

    Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

    Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 functio...

    Viktoria Gusarova, Colm O’Dushlaine, Tanya M. Teslovich in Nature Communications (2018)

  2. Article

    Open Access

    Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes

    Body fat distribution is a major, heritable risk factor for cardiometabolic disease, independent of overall adiposity. Using exome-sequencing in 618,375 individuals (including 160,058 non-Europeans) from the U...

    Parsa Akbari, Olukayode A. Sosina, Jonas Bovijn, Karl Landheer in Nature Communications (2022)