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    RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics

    Boztug and colleagues identify an immunodeficient patient with a deficiency in the guanine-nucleotide-exchange factor RASGRP1. They find that human RASGRP1 is important for the function of T cells, B cells and...

    Elisabeth Salzer, Deniz Cagdas, Miroslav Hons, Emily M Mace… in Nature Immunology (2016)