3 Result(s)
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Valerio Bianchi
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessHominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
Speciation is associated with substantial rewiring of the regulatory circuitry underlying the expression of genes. Determining which changes are relevant and underlie the emergence of the human brain or its un...
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Article
Open AccessAn enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
Mutations and variations in and around SCN5A, encoding the major cardiac sodium channel, influence impulse conduction and are associated with a broad spectrum of arrhythmia disorders. Here, we identify an evoluti...
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Article
Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis
Global transcriptional and epigenomic analyses in diverse cell types reveal that the primary action of Myc is to up- and downregulate transcription of distinct groups of genes, rather than to amplify transcrip...
