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  1. Article

    Open Access

    TGS1 mediates 2,2,7-trimethyl guanosine cap** of the human telomerase RNA to direct telomerase dependent telomere maintenance

    Pathways that direct the selection of the telomerase-dependent or recombination-based, alternative lengthening of telomere (ALT) maintenance pathway in cancer cells are poorly understood. Using human lung canc...

    Valentina Buemi, Odessa Schillaci, Mariangela Santorsola… in Nature Communications (2022)

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  2. Article

    Open Access

    SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

    In vertebrates, the telomere repeat containing long, non-coding RNA TERRA is prone to form RNA:DNA hybrids at telomeres. This results in the formation of R-loop structures, replication stress and telomere inst...

    Eleonora Petti, Valentina Buemi, Antonina Zappone… in Nature Communications (2019)

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