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    Article

    Antiplatelet and Antithrombotic Properties of Compound L-36, a 6H-1,3,4-Thiadiazine Derivative

    Compound L-36, a new derivative of 6H-1,3,4-thiadiazine, was studied in in vitro and in vivo experiments. This compound exhibits high antiplatelet and antithrombogenic activity. In in vitro experiments, compound ...

    V. S. Sirotenko, A. A. Spasov in Bulletin of Experimental Biology and Medic… (2024)

  2. Article

    Antiplatelet Activity of Riamilovir under Conditions of Lipopolysaccharide Intoxication

    We studied the effect of antiviral agent riamilovir on ADP-induced platelet aggregation in the absence and presence of LPS. Unlike acetylsalicylic acid (reference drug), riamilovir did not exhibit antiplatelet...

    A. A. Spasov, A. F. Kucheryavenko in Bulletin of Experimental Biology and Medic… (2022)

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    Antithrombotic Activity of the Antiplatelet Agent Angipur on the Model of Arterial Thrombosis in Rats with Isoproterenol-Induced Myocardial Infarction

    We studied the effect of Angipur on the process of experimental thrombosis induced by damage to the carotid artery wall by surface application of 50% ferric chloride (III) solution in rats without comorbiditie...

    A. A. Spasov, A. F. Kucheryavenko in Bulletin of Experimental Biology and Medic… (2022)

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    Article

    Antithrombotic Activity of a Novel Diazepino[1,2-α] Benzimidazole Derivative on Arterial Thrombosis Model in Rats without Concomitant Pathology and in Rats with Experimental Myocardial Infarction

    Antithrombotic activity of a novel tricyclic derivative of diazepino[1,2-α]benzimidazole (DAB-15) was examined on the model of arterial thrombosis developed in rats without concomitant pathology and in rats wi...

    A. A. Spasov, A. F. Kucheryavenko in Bulletin of Experimental Biology and Medic… (2019)

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    Article

    Antithrombotic Activity of DAB-15, a Novel Diazepinobenzimidazole Compound

    Antithrombotic activity of a new orally administered antiplatelet compound DAB-15 was compared to that of acetylsalicylic acid, ticlopidine, and clopidogrel in the experimental model of arterial thrombosis in ...

    A. A. Spasov, A. F. Kucheryavenko in Bulletin of Experimental Biology and Medic… (2017)