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Article
Synthesis of 6-alkyl-4-[5-dialkylaminomethyl-4-(4-methyl-1,3-thiazol-2-yl)-1H-pyrazol-3-yl]-1,3-benzenediols
6-Alkyl-2-dialkylaminomethyl-7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-4H-chromen-4-ones recyclized into 6-alkyl-4-[5-dialkylaminomethyl-4-(4-methyl-1,3-thiazol-2-yl)-1H-pyrazol-3-yl]-1,3-benzenediols under the inf...
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Article
Synthesis of 3-hetaryl-1H-isochromen-1-ones based on 3-(2-bromoacetyl)-1H-isochromen-1-one
A preparative method was developed for the synthesis of 3-(2-bromoacetyl)-1H-isochromen-1-one. Its heterocyclization to 3-(2-R-thiazol-4-yl)-, (3-quinoxalin-2-yl)-, and 3-(imidazo[1,2-a]pyridin-2-yl)-1H-isochrome...
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Article
Synthesis of 6-alkyl-2-dialkylaminomethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-ones
Amination of 6-alkyl-2-chloromethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-ones by secon-dary cyclic amines gives the corresponding 2-dialkylaminomethyl derivatives.
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Article
Chemistry of 3-hetarylcoumarins 3*. Synthesis and aminomethylation of 7′-hydroxy-3,4′- bicoumarins
An improved procedure for the synthesis of 7′-hydroxy-3,4′-bicoumarins has been developed. Their 8′-aminomethyl derivatives were obtained by interaction with aminals.
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Article
Features of the α-azolyl-2-hydroxy-acetophenones reaction with chloroacetyl chloride
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Article
Reduction of 3-(carboxyaryl)isocoumarins with sodium borohydride
Reduction of 3-(carboxyaryl)isocoumarins with sodium borohydride proceeds with formation of corresponding 3-carboxyaryl-3,4-dihydroisocoumarins or isomeric dihydrophthalides, 3-(2-carb-oxybenzyl)-2-benzofuran-1(3
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Article
Formylation of 5-hydroxybenzofuran derivatives and synthesis of furo-[3,2-f]coumarins based on them*
The formylation of esters of 5-hydroxy-1-benzofuran-3-carboxylic acid has been studied. The interaction of the synthesized aldehydes with esters of β-keto acids and hetarylacetonitriles gave furo[3,2-f]coumarin-1...
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Article
Synthesis and biological activity of chromones annelated at the C(7)–C(8) bond with heterocycles (review)
Published data on the synthesis of chromones annelated at the C(7)–C(8) bond with nitrogen-, oxygen-, and sulfur-containing heterocycles of various sizes, including those with two and three heteroatoms, are di...
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Article
Reaction of methyl 3-[(dimethylamino)methylidene]-6-fluoro-4-oxo −3,4-dihydrochroman-2-carboxylate with primary and secondary amines*
A method was developed for substitution of the dimethylamino group by bioisosteric fragments by the action of various primary and secondary amines on methyl 3-[(dimethylamino)methylidene]-6-fluoro-4-oxo-3,4-di...
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Article
Synthesis of derivatives of the hydrazones of 5-phenylfuro[3,2-g]chromen-7-ones
Sulfur- and nitrogen-containing derivatives of 5-phenylfurocoumarins at the exocyclic oxygen atom were synthesized. The reaction of the obtained hydrazones with certain carbonyl compounds was investigated.
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Article
3-[2(4)-Pyrimidinyl]coumarins and their condensed analogs
3-Pyrimidinylcoumarins have been synthesized by interacting 2- and 4-pyrimidinylacetonitriles with substituted salicylic aldehydes, but 9-pyrimidinylpyrano[2,3-f]chromene-4,8-diones were obtained with 8-formyl...
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Article
Furyl analogs of α-pyrono[2,3-f]isoflavones with an azole substituent in the α-pyrone nucleus
The corresponding 9-azolyl-8-imino-4H,8H-pyrano[2,3-f]chromen-4-ones have been synthesized by the condensation of 7-hydroxy-3-(5-methoxycarbonyl-2-methylfuran-3-yl)-8-formylchromones with 2-aza-hetarylacetonitril...
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Article
Aminomethylation of 3-aryl-7-hydroxycoumarins
The reaction of the analogs of natural 3-arylbenzopyran-2-ones with electrophilic reagents of aminal structure was studied. Substituted 8-aminomethyl-3-aryl-7-hydroxycoumarins were synthesized. The optimum con...
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Article
Features of the aminomethylation of 7-hydroxy-4′-fluoroisoflavones with primary amines
The behavior of 7-hydroxy-4′-fluoroisoflavones under the conditions of the Mannich reaction with primary amines was studied. New 9-alkyl-substituted 3-(4-fluorophenyl)-9,10-dihydro-4H,8H-chromeno-[8,7-e][1,3]o...
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Article
Synthesis and properties of 4-(3-amino-2-benzofuranyl)-coumarins
The alkylation of o-cyanophenol by 4-chloromethylcoumarins and subsequent intramolecular condensation by the cyano and methylene groups gives substituted 4-(3-amino-2-benzo-furanyl)coumarins. We studied the re...
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Article
Synthesis of 9-azolyl-3-(4-phenyl-4h-1,2,4-triazol-3-yl)-4h,8h-pyrano-[2,3-f]chromene-4,8-diones
The reaction of 6-ethyl-8-formyl-7-hydroxy-3-(4-phenyl-4H-1,2,4-triazol-3-yl)chromone with 2-azolyl-acetonitriles gave 8-iminopyrano[2,3-f]chromen-4-ones, whose acid hydrolysis led to pyrano-[2,3-f]chromene-4,8-d...
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Article
Convenient method for synthesis of 3-(het)-aryl-8-formyl-7-hydroxy-chromones
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Article
Synthesis and properties of 4-chloromethyl-6-hydroxy-coumarins and 4-(2-benzofuryl)-6-hydroxycoumarins
New 4-chloromethyl-6-hydroxycoumarins have been obtained by the condensation of hydroquinone derivatives with 4-chloroacetoacetic ester, and have been used for the synthesis of 4-(2-benzofuryl)-6-hydroxycoumar...
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Article
Chemistry of hetero analogs of isoflavones 26. Synthesis of 2-alkyl derivatives of 3-(thiazol-2-yl)-and 3-(benzothiazol-2-yl)chromones
Treatment of substituted 2-(2,4-dihydroxyphenacyl)thiazole and 2-(2,4-dihydroxyphenacyl)benzothiazole with propionic and isobutyric anhydrides gives the substituted 2-ethyl-and 2-isopropyl-7-acyloxychromones. ...
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Article
Synthesis of amino acid derivatives of hydrazones and oximes of spirodihydropyranochromen-2-ones
Sulfur-and nitrogen-containing derivatives of spirodihydropyranochromen-2-ones at the exocyclic oxygen atom have been synthesized. Modification of the oximes and hydrazones of the spiro-substituted pyranocouma...