9 Result(s)

Article

Phase III trial of postoperative cisplatin, interferon alpha-2b, and 5-FU combined with external radiation treatment versus 5-FU alone for patients with resected pancreatic adenocarcinoma – CapRI: study protocol [ISRCTN62866759]

After surgical intervention with curative intention in specialised centres the five-year survival of patients with carcinoma of the exocrine pancreas is only 15%. The ESPAC-1 trial showed an increased five-yea...

HP Knaebel, A Märten, J Schmidt, K Hoffmann, C Seiler, K Lindel… in BMC Cancer (2005)

Article

Preclinical evaluation of the antiproliferative potential of STI571 in Hodgkin's disease

STI571 is a selective tyrosine kinase inhibitor with proven therapeutic potential in malignancies expressing c-kit. A strong c-kit and stem cell factor expression was detected in the Hodgkin and Reed Sternberg ce...

D Re, C Wickenhauser, T Ahmadi, E Buchdunger, M Kochanek… in British Journal of Cancer (2002)

Article

Loss of heterozygosity in the Hodgkin-Reed Sternberg cell line L1236

Hodgkin-Reed Sternberg cells are derived from germinal centre B-cells in most cases. Somatic mutations affecting their rearranged immunoglobulin genes were detected, rendering potential functional rearrangemen...

A Staratschek-Jox, R Kurt Thomas, T Zander, N Massoudi… in British Journal of Cancer (2001)

Article

An anti-CD30 single-chain Fv selected by phage display and fused to Pseudomonas exotoxin A (Ki-4(scFv)-ETA’) is a potent immunotoxin against a Hodgkin-derived cell line

The human CD30 receptor is highly overexpressed on the surface of Hodgkin Reed-Sternberg cells and has been shown to be an excellent target for selective immunotherapy using monoclonal antibody-based agents su...

A Klimka, S Barth, B Matthey, R C Roovers, H Lemke, H Hansen… in British Journal of Cancer (1999)

Article

Morbus Hodgkin in adults: Preliminary results of the HD1, HD2 and HD3 trials

V. Diehl, M. Pfreundschuh, F. E. Hauser… in Journal of Cancer Research and Clinical On… (1986)

Article

Rosette inhibiting factor (RIF) produced by Hodgkin-cell lines

I. Katay, E. Zittlau, H. Burrichter… in Journal of Cancer Research and Clinical On… (1986)

Article

Phase-I-trial of tumor-necrosis-factor in patients with malignant disease

M. Pfreundschuh, T. Steinmetz, R. Gähl… in Journal of Cancer Research and Clinical On… (1986)

Article

Homogeneous growth of tumor cell colonies in agar containing glas capillaries

B. Lathan, K. Kerkhoff, W. Scheithauer… in Journal of Cancer Research and Clinical On… (1986)

Article

Immunohistological analysis of Hodgkin's and Sternberg-Reed cells: Detection of a new antigen and evidence for selective IgG uptake in the absence of B cell, T cell and histiocytic markers

To help clarify the origin and nature of Hodgkin's (H) and Sternberg-Reed (SR) cells, three different sets of experiments were performed. First, it was shown that cytoplasmic γ, ϰ, and λ occur not only in H an...

H. Stein, J. Gerdes, H. Kirchner, V. diehl… in Journal of Cancer Research and Clinical On… (1981)