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6 Result(s)
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Tsukasa Mizuhara
English
Virology
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Book
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Chapter
Conclusions
The author developed efficient methodology for the synthesis of tricyclic heterocycles related to PD 404182 based on the sp2-carbon–heteroatom (O, N, and S) bond formations by C–H functionalization or SNAr reacti...
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Chapter
Design and Synthesis of Photoaffinity Probes and Their Application to Target Identification Study of PD 404182
To investigate the mechanism of action of the potent antiviral compound PD 404182, three novel photoaffinity probes were designed and synthesized based on the structure–activity relationship studies. These pro...
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Chapter
Introduction
Highly active antiretroviral therapy suppresses HIV replication to control disease progression in HIV-infected patients. However, the emergence of drug-resistant HIV variants and drug-related adverse effects h...
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Development of Divergent Synthetic Methods of Pyrimidobenzothiazine and Related Tricyclic Heterocycles
Cu(II)-mediated novel oxidative intermolecular ortho C–H functionalization using tetrahydropyrimidine as the directing group has been investigated. Reaction of 2-phenyl-1,4,5,6- tetrahydropyrimidine with Cu(OAc)2
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Chapter
Structure–Activity Relationship Study of PD 404182 Derivatives for the Highly Potent Anti-HIV Agents
Using facile synthetic approaches to pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic derivatives, the parallel structural optimizations were investigated for the central 1,3-thiazin-2-imine cor...
