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    Article

    Multiple sclerosis patient-derived spontaneous B cells have distinct EBV and host gene expression profiles in active disease

    Epstein–Barr virus (EBV) is an aetiologic risk factor for the development of multiple sclerosis (MS). However, the role of EBV-infected B cells in the immunopathology of MS is not well understood. Here we char...

    Samantha S. Soldan, Chenhe Su, Maria Chiara Monaco, Leena Yoon… in Nature Microbiology (2024)

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    Article

    Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer

    Acetate metabolism is an important metabolic pathway in many cancers and is controlled by acetyl-CoA synthetase 2 (ACSS2), an enzyme that catalyzes the conversion of acetate to acetyl-CoA. While the metabolic ...

    Katelyn D. Miller, Seamus O’Connor, Katherine A. Pniewski, Toshitha Kannan… in Nature Cancer (2023)