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  1. Article

    Open Access

    CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia

    GABAergic dysfunctions have been implicated in the pathogenesis of schizophrenia, especially the associated cognitive impairments. The GABA synthetic enzyme glutamate decarboxylase 67-kDa isoform (GAD67) encod...

    Kazuyuki Fujihara, Kazuo Yamada, Yukio Ichitani… in Translational Psychiatry (2020)

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  2. Article

    Glutamate Decarboxylase 67 Deficiency in a Subset of GABAergic Neurons Induces Schizophrenia-Related Phenotypes

    Decreased expression of the GABA synthetic enzyme glutamate decarboxylase 67 (GAD67) in a subset of GABAergic neurons, including parvalbumin (PV)-expressing neurons, has been observed in postmortem brain studi...

    Kazuyuki Fujihara, Hideki Miwa, Toshikazu Kakizaki… in Neuropsychopharmacology (2015)

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