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Open AccessIntravenous abatacept in Japanese patients with polyarticular-course juvenile idiopathic arthritis: results from a phase III open-label study
To investigate efficacy and safety of intravenous abatacept in Japanese patients with active polyarticular-course juvenile idiopathic arthritis (pJIA).
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Article
Open AccessIdentification of candidate diagnostic serum biomarkers for Kawasaki disease using proteomic analysis
Kawasaki disease (KD) is a systemic vasculitis and childhood febrile disease that can lead to cardiovascular complications. The diagnosis of KD depends on its clinical features, and thus it is sometimes diffic...
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Open AccessUpdate of the japanese national registry of pediatric rheumatic disease
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Open AccessEfficacy, pharmacokinetics, and safety of adalimumab in pediatric patients with juvenile idiopathic arthritis in Japan
The objective of this study was to evaluate the efficacy, pharmacokinetics, and safety of adalimumab in patients with polyarticular juvenile idiopathic arthritis (JIA) in Japan. Patients aged 4 to 17 years wer...
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Open AccessTocilizumab-effects on growth impairment in systemic juvenile idiopathic arthritis
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Open AccessCorrelation between clinical indices and findings of joint ultrasonography in juvenile idiopathic arthritis with adalimumab therapy
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Open AccessEffect of anakinra on arthropathy in CINCA/NOMID syndrome
CINCA/NOMID is an autoinflammatory disorder characterized by the triad of neonatal onset of cutaneous symptoms, chronic meningitis, and recurrent fever and it presents with distinctive osteoarthropathy, synovi...
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Open AccessEfficacy of thalidomide in a girl with inflammatory calcinosis, a severe complication of juvenile dermatomyositis
We report a 14-year-old girl with juvenile dermatomyositis (JDM) complicated by severe inflammatory calcinosis successfully treated with thalidomide. She was diagnosed as JDM when she was 4 years old after a f...
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Open AccessMethotrexate for the treatment of juvenile idiopathic arthritis: process to approval for JIA indication in Japan
Methotrexate (MTX), the primary treatment for the articular-type juvenile idiopathic arthritis (JIA), is effective and brings about radiological improvement. Patient compliance is good, and it is recognized th...
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Cross-cultural adaptation and validation of the Japanese version of the Childhood Health Assessment Questionnaire (CHAQ)
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Open AccessSerum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy
Systemic-onset juvenile idiopathic arthritis (SJIA) is a disease of unknown etiology with an unpredictable response to treatment. We examined two groups of patients to determine whether there are serum protein...
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Two-generation Kawasaki Disease: Mother and Daugher
Evidence that the incidence of Kawasaki disease (KD) in siblings is much higher than general incidence, indicates that genetic factors may contribute to the susceptibility. We report a girl with KD whose mothe...
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Effect of Plasma Exchange in Kawasaki Disease Refractory to High Dose Intravenous Gammaglobulin Therapy
Background: In Kawasaki disease (KD), administration of intravenous gammma-globulin (IVGG) reduced frequency of coronary artery lesion (CAL) from 25% to 8%. However, approximately 500 children still develop CAL e...
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Hypercytokinemia is Not Originated from Peripheral Mononuclear Cells at Acute Phase of Kawasaki Disease
Immune activation and generalized vasculitis are two central features of Kawasaki disease (KD). Recent observations indicated that serum levels of cytokines including interferon(INF)- γ, tumor necrosis factor ...