10 Result(s)

Article

Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression

Novel therapeutic strategies are urgently required for osteosarcoma, given the early age at onset and persistently high mortality rate. Modern transcriptomics techniques can identify differentially expressed g...

Kentaro Watanabe, Keiji Tasaka, Hideto Ogata, Shota Kato, Hiroo Ueno… in Cancer Gene Therapy (2024)

Article

Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages

Katherine Sturgess, Eliza Yankova, M. S. Vijayabaskar, Tomoya Isobe… in Leukemia (2023)

Article

Identification of the ultrahigh-risk subgroup in neuroblastoma cases through DNA methylation analysis and its treatment exploiting cancer metabolism

Neuroblastomas require novel therapies that are based on the exploitation of their biological mechanism. To address this need, we analyzed the DNA methylation and expression datasets of neuroblastomas, extract...

Kentaro Watanabe, Shunsuke Kimura, Masafumi Seki, Tomoya Isobe, Yasuo Kubota… in Oncogene (2022)

Article

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) represents the most refractory type of childhood leukemia. To uncover the molecular heterogeneity of this disease, we perform RNA sequencing, methylation...

Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura… in Nature Communications (2022)

Article

Comprehensive genetic analysis of pediatric germ cell tumors identifies potential drug targets

To elucidate the molecular pathogenesis of pediatric germ cell tumors (GCTs), we performed DNA methylation array analysis, whole transcriptome sequencing, targeted capture sequencing, and single-nucleotide pol...

Yasuo Kubota, Masafumi Seki, Tomoko Kawai, Tomoya Isobe… in Communications Biology (2020)

Article

Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets

Although hepatoblastoma is the most common pediatric liver cancer, its genetic heterogeneity and therapeutic targets are not well elucidated. Therefore, we conducted a multiomics analysis, including mutatome, ...

Masahiro Sekiguchi, Masafumi Seki, Tomoko Kawai, Kenichi Yoshida… in npj Precision Oncology (2020)