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  1. No Access

    Article

    Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity

    MEF2D fusion genes are newly discovered recurrent gene abnormalities that are detected in approximately 5% of acute lymphoblastic leukemia cases. We previously demonstrated that the vector-driven expression of...

    Daiki Hirano, Fumihiko Hayakawa, Takahiko Yasuda, Naoyuki Tange… in Oncogene (2019)

  2. No Access

    Article

    Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation

    The transcription factor GATA-1 plays a significant role in erythroid differentiation and association with CBP stimulates its activity by acetylation. It is possible that histone deacetylases (HDACs) repress t...

    Kouichi Watamoto, Masayuki Towatari, Yukiyasu Ozawa, Yasuhiko Miyata… in Oncogene (2003)

  3. No Access

    Article

    Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain

    Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly associated with leukocytosis and a poor prognosis....

    Hitoshi Kiyoi, Ryuzo Ohno, Ryuzo Ueda, Hidehiko Saito, Tomoki Naoe in Oncogene (2002)

  4. No Access

    Article

    Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

    We have recently identified an internal tandem duplication of the human Flt3 gene in approximately 20% of acute myeloid leukemia (AML) cases. In the present study, the wild-type and the mutant Flt3 genes were ...

    Fumihiko Hayakawa, Masayuki Towatari, Hitoshi Kiyoi, Mitsune Tanimoto… in Oncogene (2000)