11 Result(s)
within
Tommaso Mazza
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessThe Notch1 signaling pathway directly modulates the human RANKL-induced osteoclastogenesis
Notch signaling is an evolutionary conserved pathway with a key role in tissue homeostasis, differentiation and proliferation. It was reported that Notch1 receptor negatively regulates mouse osteoclast develop...
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Article
Open AccessMultiple-core-hole resonance spectroscopy with ultraintense X-ray pulses
Understanding the interaction of intense, femtosecond X-ray pulses with heavy atoms is crucial for gaining insights into the structure and dynamics of matter. One key aspect of nonlinear light–matter interacti...
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Article
Open AccessAPOGEE 2: multi-layer machine-learning model for the interpretable prediction of mitochondrial missense variants
Mitochondrial dysfunction has pleiotropic effects and is frequently caused by mitochondrial DNA mutations. However, factors such as significant variability in clinical manifestations make interpreting the path...
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Article
Open AccessMining potentially actionable kinase gene fusions in cancer cell lines with the KuNG FU database
Inhibition of kinase gene fusions (KGFs) has proven successful in cancer treatment and continues to represent an attractive research area, due to kinase druggability and clinical validation. Indeed, literature...
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Article
Attosecond pulse sha** using a seeded free-electron laser
Attosecond pulses are central to the investigation of valence- and core-electron dynamics on their natural timescales1–3. The reproducible generation and characterization of attosecond waveforms has been demonstr...
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Article
Open AccessThe striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses
Previous evidence pointed out a role for the striatal-enriched protein Rhes in modulating dopaminergic transmission. Based on the knowledge that cocaine induces both addiction and motor stimulation, through it...
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Article
Open AccessHsa-miR-210-3p expression in breast cancer and its putative association with worse outcome in patients treated with Docetaxel
MicroRNA-210-3p is the most prominent hypoxia regulated microRNA, and it has been found significantly overexpressed in different human cancers. We performed the expression analysis of miR-210-3p in a retrospec...
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Article
Open AccessStepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients
miR-9 was initially identified as an epigenetically regulated miRNA in tumours, but inconsistent findings have been reported so far. We analysed the expression of miR-9-5p, miR-9-3p, pri-miRs and MIR9 promoters m...
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Article
Open AccessChirped pulse amplification in an extreme-ultraviolet free-electron laser
Chirped pulse amplification in optical lasers is a revolutionary technique, which allows the generation of extremely powerful femtosecond pulses in the infrared and visible spectral ranges. Such pulses are now...
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Article
Open AccessIdentification of p53-target genes in Danio rerio
To orchestrate the genomic response to cellular stress signals, p53 recognizes and binds to DNA containing specific and well-characterized p53-responsive elements (REs). Differences in RE sequences can strongl...
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Article
Open AccessGene expression of muscular and neuronal pathways is cooperatively dysregulated in patients with idiopathic achalasia
Idiopathic achalasia is characterized by the absence of peristalsis secondary to loss of neurons in the myenteric plexus that hampers proper relaxation of the lower esophageal sphincter. Achalasia can be consi...
