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Article
Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors
A targeting method for lentiviral vectors relying on the use of single-chain antibodies recognizing cell-surface antigens is applied to generate lentiviral vectors specific for endothelial cells, hematopoietic...
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Article
Open AccessFast responsive, optical trace level ammonia sensor for environmental monitoring
Ammonia is a ubiquitous chemical substance which is created in technical and biological processes and harmful to many different organisms. One specific problem is the toxicity of ammonia in fish at levels of 2...
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Article
Filter-free integrated sensor array based on luminescence and absorbance measurements using ring-shaped organic photodiodes
An optical waveguiding sensor array featuring monolithically integrated organic photodiodes as integrated photo-detector, which simplifies the readout system by minimizing the required parts, is presented. The...
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Article
Screen-printed polymer waveguides for integrated optics
We demonstrate screen printing of polymer waveguides on rigid and flexible substrates. The waveguides are characterized by optical microscopy and propagation losses are determined by cut-back measurements. Fur...
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Article
Enabling luminescence decay time-based sensing using integrated organic photodiodes
The use of organic photodiodes (OPDs) for measuring phosphorescent lifetimes of optochemical oxygen sensors is described. Phosphorescent indicators with lifetimes ranging from ∼5 to 60 μs have been studied usi...
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Article
Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model
Alzheimer’s disease (AD) is characterized by synaptic failure, dendritic and axonal atrophy, neuronal death and progressive loss of cognitive functions. It is commonly assumed that these deficits arise due to ...
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Article
Open AccessPreclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation
A primary goal in transplantation medicine is the induction of a tolerogenic environment for prevention of transplant rejection without the need for long-term pharmacological immunosuppression. Generation of a...
