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  1. Article

    Open Access

    Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells

    Triple-negative breast cancer (TNBC) is associated with aggressiveness and a poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for TNBC. However, response to radiotherapy is ...

    Shayan Khozooei, Konstanze Lettau in Journal of Experimental & Clinical Cancer … (2022)

  2. Article

    Open Access

    PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts

    PARP inhibitors niraparib and talazoparib are FDA approved for special cases of breast cancer. PARP is an interesting repair protein which is frequently affected in cancer cells. We studied the combined action...

    Verena Weigert, Tina Jost, Markus Hecht, Ilka Knippertz, Lucie Heinzerling in BMC Cancer (2020)