13 Result(s)
within
Timothy Morgan
English
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Article
Open AccessIntegrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis
We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase. Using data from 12 cohorts, including 1...
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Angioplasty Induced Changes in Dialysis Vascular Access Compliance
Dialysis vascular access remains vitally important to maintain life and functional capacity with end stage renal disease. Angioplasty is an integral part of maintaining dialysis access function and patency. To...
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Open AccessImpact of underground storm drain systems on larval ecology of Culex and Aedes species in urban environments of Southern California
An extensive network of storm water conveyance systems in urban areas, often referred to as the “underground storm drain system” (USDS), serves as significant production habitats for mosquitoes. Knowledge of w...
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CBD Suppression of EAE Is Correlated with Early Inhibition of Splenic IFN-γ + CD8+ T Cells and Modest Inhibition of Neuroinflammation
In this study cannabidiol (CBD) was administered orally to determine its effects and mechanisms in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). We hypothesized that 75 ...
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Article
Open AccessGetting to implementation: a protocol for a Hybrid III stepped wedge cluster randomized evaluation of using data-driven implementation strategies to improve cirrhosis care for Veterans
Cirrhosis is a rapidly increasing cause of global mortality. To improve cirrhosis care, the Veterans Health Administration (VHA) developed the Hepatic Innovation Team (HIT) Collaborative to support VA Medical...
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Improved Survival Among all Interferon-α-Treated Patients in HCV-002, a Veterans Affairs Hepatitis C Cohort of 2211 Patients, Despite Increased Cirrhosis Among Nonresponders
As the era of interferon-alpha (IFN)-based therapy for hepatitis C ends, long-term treatment outcomes are now being evaluated.
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Open AccessThe impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population
Ingestion of polyunsaturated fatty acids (PUFAs) has been proposed to influence several chronic diseases including coronary heart disease (CHD) and type-2 diabetes (T2D). There is strong evidence that omega-3 ...
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Article
Protein restriction in hepatic encephalopathy is appropriate for selected patients: a point of view
Since the late nineteenth century, protein restriction has been shown to improve hepatic encephalopathy. However, malnutrition has been described in up to 60 % of cirrhotic patients and is associated with incr...
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Article
Open AccessHigh rates of early treatment discontinuation in hepatitis C-infected US veterans
Patients with chronic hepatitis C (HCV) frequently discontinued dual therapy with pegylated interferon alfa (Peg-IFN) plus ribavirin (RBV) before reaching the recommended duration of 48 or 24 weeks for genotyp...
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Open AccessTesting Beneficial Therapy in Human Cirrhosis Using Animal Models of Cirrhosis
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Open AccessCarotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors
Surrogate measures for cardiovascular disease events have the potential to increase greatly the efficiency of clinical trials. A leading candidate for such a surrogate is the progression of intima-media thickn...
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Article
Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis
The filamins are cytoplasmic proteins that regulate the structure and activity of the cytoskeleton by cross-linking actin into three-dimensional networks, linking the cell membrane to the cytoskeleton and serv...
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Article
Examining the Impact of Missing Data on Propensity Score Estimation in Determining the Effectiveness of Self-Monitoring of Blood Glucose (SMBG)
In many health services applications, research to determine the effectiveness of a particular treatment cannot be carried out using a controlled clinical trial. In settings such as these, observational studies...
