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    Protocol

    Biosynthesis of Glycoconjugate Virus-like Particles (VLPs)

    The outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures—polysaccharides, glycolipids, and glycoproteins. To raise a long-lasting and effective immune response against...

    Kathryn K. Oi, Tom A. Kloter, Timothy G. Keys in Vaccine Delivery Technology (2021)

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    Article

    Engineering the product profile of a polysialyltransferase

    Functional assessments and applications of polysaccharides are hampered by broad product distributions. Neutral drift libraries now identify specific amino acids and binding sites that determine product outcom...

    Timothy G Keys, Hazel L S Fuchs, Jörg Ehrit, Jürgen Alves… in Nature Chemical Biology (2014)