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Article
Open AccessAll Your Base: a fast and accurate probabilistic approach to base calling
The accuracy of base calls produced by Illumina sequencers is adversely affected by several processes, with laser cross-talk and cluster phasing being prominent. We introduce an explicit statistical model of t...
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Article
Open AccessGenomic DNA k-mer spectra: models and modalities
The empirical frequencies of DNA k-mers in whole genome sequences provide an interesting perspective on genomic complexity, and the availability of large segments of genomic sequence from many organisms means tha...
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Article
Open AccessRelating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins
Gene duplications have been hypothesized to be a major factor in enabling the evolution of tissue differentiation. Analyses of the expression profiles of duplicate genes in mammalian tissues have indicated tha...
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Article
Open AccessRelationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins
The combination of complete genome sequence information with expression data enables us to characterize the relationship between a protein's evolutionary origin or functional category and its expression patter...