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Article
Open AccessThe m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway
Glioma is the most common and aggressive type of primary malignant brain tumor. The N6-methyladenosine (m6A) modification widely exists in eukaryotic cells and plays an important role in the occurrence and dev...
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Article
Transumbilical Stapling Technic of OAGB
Single-port or single-incision laparoscopic surgery (SILS) is esteemed for its efficacy in achieving superior postoperative cosmetic outcomes compared to the conventional laparoscopic approach (Behnia-Willison...
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Article
Clinical and genetic characterization of a large cohort of Chinese patients with Bietti crystalline retinopathy
To investigate the clinical and genetic characteristics for a large cohort of Chinese patients with Bietti crystalline retinopathy (BCR).
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Article
Leber congenital amaurosis as the initial and essential manifestation in a Chinese patient with autoimmune polyglandular syndrome Type 1
Autoimmune polyglandular syndrome Type 1 (APS-1) is a rare autosomal recessive disorder caused by defects in the autoimmune regulator (AIRE) gene. Patients are generally diagnosed at ages between five and fifteen...
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Article
Research trends and hotspots of neoadjuvant therapy in pancreatic cancer: a bibliometric analysis based on the Web of Science Core Collection
Neoadjuvant therapy (NAT) for pancreatic cancer (PC) has achieved certain results. This article was aimed to analyze the trends in NAT in PC over the past 20 years using bibliometric analysis and visualization...
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Article
Open AccessThe Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease
Alcoholic liver disease (ALD) and other forms of chronic hepatotoxic injury can lead to transforming growth factor β1 (TGFβ1)-induced hepatic fibrosis and compromised liver function, underscoring the need to d...
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Article
Open AccessOptimal strategy of the simultaneous dice game Pig for multiplayers: when reinforcement learning meets game theory
In this work, we focus on using reinforcement learning and game theory to solve for the optimal strategies for the dice game Pig, in a novel simultaneous playing setting. First, we derived analytically the opt...
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Article
Genetic analysis and clinical features of three Chinese patients with Oguchi disease
Oguchi disease is a rare autosomal recessive form of congenital stationary night blindness caused by disease-causing variants in the rhodopsin kinase gene (GRK1) or the arrestin gene (SAG). Our study aims to desc...
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Article
Association between the Severity of Sarcopenia and Pneumonia in Patients with Stable Schizophrenia: A Prospective Study
This study investigates the associations between the severity of sarcopenia and pneumonia in patients with stable schizophrenia.
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Article
A novel tandem duplication of PRDM13 in a Chinese family with North Carolina macular dystrophy
North Carolina macular dystrophy (NCMD) is a rare autosomal dominant inherited disorder characterized by macular impairment with a variety of phenotypic manifestations. The aims of this study were to assess th...
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Chapter and Conference Paper
Trichomonas Vaginalis Segmentation in Microscope Images
Trichomoniasis is a common infectious disease with high incidence caused by the parasite Trichomonas vaginalis, increasing the risk of getting HIV in humans if left untreated. Automated detection of Trichomona...
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Article
Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway
Liquiritin (LIQ), a major constituent of Glycyrrhiza Radix, exhibits various pharmacological activities. In this study, to explore the potential anti-cancer effects and its underlying molecular mechanisms of L...
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Chapter and Conference Paper
Designing Virtual Equipment Systems for VR
Skeuomorphism in virtual reality can provide more than just visual cues for quick recognition, it can also provide spatial information. A Virtual Equipment System is a system that takes advantage of the spatia...
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Chapter and Conference Paper
Using Reinforcement Learning Agents to Analyze Player Experience
Analyzing player experience often requires collecting lots of gameplay data from human players, which is labor-intensive. In this paper, we present an approach to classify player experience using AI agents. A ...
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Chapter and Conference Paper
Practical DDoS Attack Group Discovery and Tracking with Complex Graph-Based Network
In recent years, a large number of users continuously suffer from DDoS attacks. DDoS attack volume is on the rise and the scale of botnets is also getting larger. Many security organizations began to use data-...
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Article
Open AccessDetermination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioide...
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Article
Research advances in neurobiological mechanism of acupuncture for amblyopia
Amblyopia greatly affects the physical and mental development of children. Acupuncture is effective for amblyopia, though its mechanism remains unclear. This article summarized the mechanism of acupuncture tre...
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Article
Effects of acupuncture on neuro-electrophysiological activities in hippocampal CA1 and CA3 areas of rats with post-traumatic stress disorder
To observe the effects of acupuncture on the characteristics of neuro-electrophysiological activity in hippocampal CA1 and CA3 areas of rats with post-traumatic stress disorder (PTSD).
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Article
Long noncoding RNA UCA1 promotes the proliferation of hypoxic human pulmonary artery smooth muscle cells
Our study explored the effects of lncRNA UCA1 on the proliferation and apoptosis in hypoxic human pulmonary artery smooth muscle cells (HPASMCs) and highlighted the endogenous relationship between UCA1, ING5, ...
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Article
Open AccessA geochemical investigation of the free and carbonate-bound organic matter in the clay-sized fraction of argillaceous source rocks and its significance for biogenic interpretation
The molecular composition and biomarker distribution of various occurrences of organic matter in argillaceous source rocks developed in fresh and saline lacustrine environments were revealed by successive trea...
