Skip to main content

3 Result(s)

within Tetsuzo Tauchi Remove this filter Human Genetics Remove this filter

and

  1. No Access

    Protocol

    Telomerase Inhibition Combined with Other Chemotherapeutic Reagents to Enhance Anti-Cancer Effect

    Genetic experiments using a dominant-negative form of human telomerase (DN-hTERT) demonstrated that telomerase inhibition can result in telomeric shortening followed by proliferation arrest and cell death by a...

    Tetsuzo Tauchi, Junko H. Ohyashiki, Kazuma Ohyashiki in Telomerase Inhibition (2007)

  2. No Access

    Article

    Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways

    The telomerase complex is responsible for telomere maintenance and represents a promising neoplasia therapeutic target. In order to determine whether G-quadruplex-interactive telomerase inhibitor, telomestatin...

    Tetsuzo Tauchi, Kazuo Shin-ya, Goro Sashida, Masahiko Sumi, Akihiro Nakajima… in Oncogene (2003)

  3. No Access

    Article

    Telomeres and telomerase in hematologic neoplasia

    Normal hematopoietic cells express telomerase activity, however the presence of telomerase does not necessarily imply stable and thus unchanging telomere length. Gradual telomere loss with aging and rapid cycl...

    Junko H Ohyashiki, Goro Sashida, Tetsuzo Tauchi, Kazuma Ohyashiki in Oncogene (2002)