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Article
Open AccessSustainable HIV treatment in Africa through viral-load-informed differentiated care
There are inefficiencies in current approaches to monitoring patients on antiretroviral therapy in sub-Saharan Africa. Patients typically attend clinics every 1 to 3 months for clinical assessment. The clinic ...
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Article
Open AccessOptimising diagnosis of viraemic hepatitis C infection: the development of a target product profile
The current low access to virological testing to confirm chronic viraemic HCV infection in low- and middle-income countries (LMIC) is limiting the rollout of hepatitis C (HCV) care. Existing tests are complex,...
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Article
Open AccessValues, preferences and current hepatitis B and C testing practices in low- and middle-income countries: results of a survey of end users and implementers
Access to hepatitis B virus (HBV) and hepatitis C virus (HCV) diagnostics remains a key bottleneck in scale-up of access to HBV and HCV treatment, particularly in low- and middle-income countries (LMICs) that ...
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Article
Open AccessDiagnostic accuracy of detection and quantification of HBV-DNA and HCV-RNA using dried blood spot (DBS) samples – a systematic review and meta-analysis
The detection and quantification of hepatitis B (HBV) DNA and hepatitis C (HCV) RNA in whole blood collected on dried blood spots (DBS) may facilitate access to diagnosis and treatment of HBV and HCV infection...
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Article
Open AccessSurvey of programmatic experiences and challenges in delivery of hepatitis B and C testing in low- and middle-income countries
There have been few reports on programmatic experience of viral hepatitis testing and treatment in resource-limited settings. To inform the development of the 2017 World Health Organization (WHO) viral hepatit...
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Article
Open AccessDiagnostic accuracy of serological diagnosis of hepatitis C and B using dried blood spot samples (DBS): two systematic reviews and meta-analyses
Dried blood spots (DBS) are a convenient tool to enable diagnostic testing for viral diseases due to transport, handling and logistical advantages over conventional venous blood sampling. A better understandin...
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Article
Open AccessPrioritising pathogens for the management of severe febrile patients to improve clinical care in low- and middle-income countries
Severe febrile illness without a known source (SFWS) is a challenge for clinicians when deciding how to manage a patient, particularly given the wide spectrum of potential aetiologies that contribute to fever....
