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Article
Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growth
C/EBP homologous protein (CHOP) triggers the death of multiple cancers via endoplasmic reticulum (ER) stress. However, the function and regulatory mechanism of CHOP in liver cancer remain elusive. We have reporte...
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Article
HBXIP induces PARP1 via WTAP-mediated m6A modification and CEBPA-activated transcription in cisplatin resistance to hepatoma
Poly (ADP-ribose) polymerase 1 (PARP1) is a DNA-binding protein that is involved in various biological functions, including DNA damage repair and transcription regulation. It plays a crucial role in cisplatin ...
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Article
Open AccessSpecific convulsions and brain damage in children hospitalized for Omicron BA.5 infection: an observational study using two cohorts
SARS-CoV-2 continues to mutate over time, and reports on children infected with Omicron BA.5 are limited. We aimed to analyze the specific symptoms of Omicron-infected children and to improve patient care.
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Article
Open AccessDeuteration-enhanced neutron contrasts to probe amorphous domain sizes in organic photovoltaic bulk heterojunction films
An organic photovoltaic bulk heterojunction comprises of a mixture of donor and acceptor materials, forming a semi-crystalline thin film with both crystalline and amorphous domains. Domain sizes critically imp...
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Article
CRF regulates pain sensation by enhancement of corticoaccumbal excitatory synaptic transmission
Both peripheral and central corticotropin-releasing factor (CRF) systems have been implicated in regulating pain sensation. However, compared with the peripheral, the mechanisms underlying central CRF system i...
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Article
Automated synthesis of oxygen-producing catalysts from Martian meteorites by a robotic AI chemist
Living on Mars requires the ability to synthesize chemicals that are essential for survival, such as oxygen, from local Martian resources. However, this is a challenging task. Here we demonstrate a robotic art...
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Article
Open AccessCircular olefin copolymers made de novo from ethylene and α-olefins
Ethylene/α-olefin copolymers are produced in huge scale and widely used, but their after-use disposal has caused plastic pollution problems. Their chemical inertness made chemical re/upcycling difficult. Ideal...
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Article
Achieving a high-performance sodium-ion pouch cell by regulating intergrowth structures in a layered oxide cathode with anionic redox
In P2-type layered transition metal (TM) oxides, which are typical cathode materials for Na-ion batteries, the presence of Li within the TM layer could lead to the formation of specific Na–O–Li configurations ...
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Article
Open AccessEBV DNA methylation profiles and its application in distinguishing nasopharyngeal carcinoma and nasal NK/T-cell lymphoma
As an oncovirus, EBV is associated with multiple cancers, including solid tumors and hematological malignancies. EBV methylation plays an important role in regulating tumor occurrence. However, the EBV methyla...
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Article
Open AccessRNA sequencing and proteomic profiling reveal alterations by MPTP in chronic stomach mucosal injury in tree shrew Chinese (Tupaia belangeri chinensis)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that can cause gastrointestinal ulcers by affecting dopamine levels. Therefore, MPTP has been considered a toxic substance that causes gastri...
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Article
Neuronal intranuclear inclusion disease with cortical involvement in left hemisphere: a case report
Neuronal intranuclear inclusion disease (NIID) is a rare highly heterogeneous disease. In this paper, we present a case of NIID featured in cortical involvement in left hemisphere of brain and the imaging chan...
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Article
A machine learning approach to TCAD model calibration for MOSFET
Machine learning-based surrogate models have significant advantages in terms of computing efficiency. In this paper, we present a pilot study on fast calibration using machine learning techniques. Technology c...
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Article
Heterointerface of all-alkynyl-protected Au28 nanoclusters anchored on NiFe-LDHs boosts oxygen evolution reaction: a case to unravel ligand effect
Ultrasmall Au nanoclusters have been proven to effectively enhance the catalytic performance of NiFe layered double hydroxides (NiFe-LDHs) toward oxygen evolution reaction (OER), yet the surface ligand effect ...
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Article
A Li-rich layered oxide cathode with negligible voltage decay
With high capacity at low cost, Li- and Mn-rich (LMR) layered oxides are a promising class of cathodes for next-generation Li-ion batteries. However, substantial voltage decay during cycling, due to the unstab...
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Article
Highly selective and stable polybenzoxazine-based carbon nanosheet supported Pd catalyst for aerobic benzyl alcohol oxidation
Small Pd nanoparticles tend to aggregate during the thermal treatment or lose during the reaction process, which lead to the decrease in activity. To solve this problem, the 2D polybenzoxazine-based polymer na...
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Article
Open AccessAssociation of dietary inflammatory index with helicobacter pylori infection and mortality among US population
Limited research has been conducted on the potential relationship between the dietary inflammation index (DII) and mortality, particularly in individuals with Helicobacter pylori (H. pylori) infection. This st...
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Article
Seamless Prediction in China: A Review
Seamless prediction is a weather–climate integrated prediction covering multiple time scales that include days, weeks, months, seasons, years, and decades. Seamless prediction can provide different industries ...
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Article
Phase transformation behavior of a dual-phase nanostructured Fe-Ni-B-Si-P-Nb metallic glass and its correlation with stress-impedance properties
A study of the phase transformation process of a Fe-Ni-B-Si-P-Nb metallic glass using a suite of advanced characterization tools is reported. Transmission electron microscopy (TEM) and small angle neutron scat...
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Article
Open AccessCombination of inclusive top-quark pair production cross-section measurements using ATLAS and CMS data at \( \sqrt{s} \) = 7 and 8 TeV
A combination of measurements of the inclusive top-quark pair production cross-section performed by ATLAS and CMS in proton–proton collisions at centre-of-mass energies of 7 and 8 TeV at the LHC is presented. ...
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Article
Open AccessIdentification and characterization of a strong constitutive promoter stnYp for activating biosynthetic genes and producing natural products in streptomyces
Streptomyces are well known for their potential to produce various pharmaceutically active compounds, the commercial development of which is often limited by the low productivity and purity of the desired compoun...
