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    Article

    Role of the cGAS-STING pathway in regulating the tumor-immune microenvironment in dMMR/MSI colorectal cancer

    Deficient mismatch repair (dMMR)/microsatellite instability (MSI) colorectal cancer (CRC) has high immunogenicity and better prognosis compared with proficient MMR (pMMR)/microsatellite stable (MSS) CRC. Altho...

    Akinao Kaneta, Shotaro Nakajima, Hirokazu Okayama in Cancer Immunology, Immunotherapy (2022)

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    Article

    SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer

    Colorectal cancer (CRC) develops through chromosomal instability (CIN) or microsatellite instability (MSI) due to deficient mismatch-repair (dMMR). We aimed to characterise novel cancer-associated genes that a...

    Takuro Matsumoto, Hirokazu Okayama, Shotaro Nakajima in British Journal of Cancer (2022)