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Article
Overexpression of SerpinB9 in non-seminomatous germ cell tumors
Serpinb9 is an inhibitor of granzyme B and is potentially involved in the immune escape of tumor cells. In the present study, bioinformatics analysis using open databases suggested that SerpinB9 is overexpress...
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Article
High T-cell infiltration in tumor tissue and younger age predict the response to pembrolizumab in recurrent urothelial cancer
Targeting the programmed cell death-1 signaling pathway has been approved for the anti-cancer therapy in several cancers including urothelial cancer. To determine predictive factors of the responsiveness to pe...
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Article
CD163-positive cancer cells are potentially associated with high malignant potential in clear cell renal cell carcinoma
CD163 is preferentially expressed by monocyte/macrophages; however, recent studies using immunohistochemistry (IHC) have reported that some cancer cells also express CD163. In the present IHC study, we investi...
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Article
Phenotypical change of tumor-associated macrophages in metastatic lesions of clear cell renal cell carcinoma
Macrophages are the main immune cells of the tumor microenvironment in clear cell renal cell carcinoma (ccRCC). A high density of CD163+ or CD204+ tumor-associated macrophages (TAMs), rather than the density of t...
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Article
The significance of TIMD4 expression in clear cell renal cell carcinoma
T-cell immunoglobulin and mucin domain (TIMD) family genes are related to innate immune responses. TIMD4 is a receptor for phosphatidylserine and is involved in the phagocytosis of apoptotic cells by macrophag...
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Article
Open AccessPD-L1 expression in papillary renal cell carcinoma
The immune escape or tolerance of cancer cells is considered to be closely involved in cancer progression. Programmed death-1 (PD-1) is an inhibitory receptor expressed on activating T cells, and several types...