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Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications

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  1. Article

    Open Access

    Ergothioneine promotes longevity and healthy aging in male mice

    Healthy aging has emerged as a crucial issue with the increase in the geriatric population worldwide. Food-derived sulfur-containing amino acid ergothioneine (ERGO) is a potential dietary supplement, which exh...

    Makoto Katsube, Takahiro Ishimoto, Yutaro Fukushima, Asuka Kagami in GeroScience (2024)

  2. Article

    Open Access

    TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans

    Oral administration of the food-derived antioxidant amino acid ergothioneine (ERGO) results in its efficient distribution in the brain and enhances cognitive function. However, effect of ERGO deficiency on cog...

    Takahiro Ishimoto, Reiya Yamashita, Ruri Matsumoto in npj Science of Food (2024)

  3. Article

    Open Access

    Dipeptide species regulate p38MAPK–Smad3 signalling to maintain chronic myelogenous leukaemia stem cells

    Understanding the specific survival of the rare chronic myelogenous leukaemia (CML) stem cell population could provide a target for therapeutics aimed at eradicating these cells. However, little is known about...

    Kazuhito Naka, Yoshie Jomen, Kaori Ishihara, Junil Kim in Nature Communications (2015)