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    Article

    Carnitine/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells

    Brain immune cells, i.e., microglia, play an important role in the maintenance of brain homeostasis, whereas chronic overactivation of microglia is involved in the development of various neurodegenerative diso...

    Takahiro Ishimoto, Noritaka Nakamichi, Hikari Nishijima… in Neurochemical Research (2018)

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    Article

    Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice

    Understanding of the underlying mechanism of epilepsy is desired since some patients fail to control their seizures. The carnitine/organic cation transporter OCTN1/SLC22A4 is expressed in brain neurons and tra...

    Misa Nishiyama, Noritaka Nakamichi, Tomoyuki Yoshimura… in Neurochemical Research (2020)

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    Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications

    Neurogenesis is the process by which new neurons are generated from neural stem cells (NSCs), which are cells that have the ability to proliferate and differentiate into neurons, astrocytes, and oligodendrocyt...

    Takahiro Ishimoto, Yukio Kato in Organic Cation Transporters in the Central Nervous System (2021)