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  1. Article

    Open Access

    Prediction of TKI response in EGFR-mutant lung cancer patients-derived organoids using malignant pleural effusion

    Patient-derived organoids (PDOs) are valuable in predicting response to cancer therapy. PDOs are ideal models for precision oncologists. However, their practical application in guiding timely clinical decision...

    Sang-Hyun Lee, Kyuhwan Kim, Eunyoung Lee, Kyungmin Lee… in npj Precision Oncology (2024)

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  2. No Access

    Article

    Posttranscriptional control of the replication stress response via TTP-mediated Claspin mRNA stabilization

    ATR and CHK1 play key roles in the protection and recovery of the stalled replication forks. Claspin, an adaptor for CHK1 activation, is essential for DNA damage signaling and efficient replication fork progre...

    Tae-Hee Lee, Ji Ye Choi, Jeong-Min Park, Tae-Hong Kang in Oncogene (2020)

  3. No Access

    Article

    Proinvasive extracellular matrix remodeling in tumor microenvironment in response to radiation

    Ionizing radiation is widely used for patient with glioblastoma (GBM). However, the effect of radiation on patient survival is marginal and upon recurrence tumors frequently shift toward mesenchymal subtype ad...

    Ki-Chun Yoo, Yongjoon Suh, Yoojeong An, Hae-June Lee, Ye Ji Jeong, Nizam Uddin… in Oncogene (2018)

  4. No Access

    Article

    The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor α-negative breast cancer cells to tamoxifen

    Many cases of breast cancer show loss of estrogen receptor (ER) α expression, which leads to unresponsiveness to antihormonal treatment even though there is no loss of the structurally and biochemically similar E...

    Eun Ryoung Jang, Soo-Jeong Lim, Eun Sook Lee, Ga** Jeong, Tae-You Kim… in Oncogene (2004)

  5. No Access

    Article

    Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells

    DLC-1 (deleted in liver cancer) gene is frequently deleted in hepatocellular carcinoma. However, little is known about the genetic status and the expression of this gene in gastric cancer. In this study, North...

    Tai Young Kim, Hyun-Soon Jong, Sang-Hyun Song, Alexandre Dimtchev… in Oncogene (2003)