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147 Result(s)
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Article
Differential surface microbial community and thalli metabolome as early indicators of disease in red algae Pyropia yezoensis
To understand pathogenic mechanisms and suggest molecular biomarker candidates for the disease status of edible red algae, Pyropia, we analyzed relationships between disease symptom severity, changes in microbial...
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Article
Open AccessTumor-derived miR-6794-5p enhances cancer growth by promoting M2 macrophage polarization
Solid tumors promote tumor malignancy through interaction with the tumor microenvironment, resulting in difficulties in tumor treatment. Therefore, it is necessary to understand the communication between cells...
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Open AccessIn vivo safety and biodistribution profile of Klotho-enhanced human urine-derived stem cells for clinical application
Urine-derived stem cells (UDSCs) can be easily isolated from urine and possess excellent stem cell characteristics, making them a promising source for cell therapeutics. Due to their kidney origin specificity,...
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Article
Bioactive Bone Substitute in a Rabbit Ulna Model: Preclinical Study
Current therapies to effectively treat long-bone defects and extensive bone tissue loss remains limited. In this study, we created a new bone substitute by integrating advanced technologies such as structure p...
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First report of Corydalis speciosa Maxim. being a natural host plant for cucumber mosaic virus in Korea
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Article
Open AccessCorrection: Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space
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Integrative analysis of risk factors for immune-related adverse events of checkpoint blockade therapy in cancer
Immune-related adverse events (irAEs) induced by checkpoint inhibitors involve a multitude of different risk factors. Here, to interrogate the multifaceted underlying mechanisms, we compiled germline exomes an...
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Open AccessOligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space
Inflammasomes are multi-protein complexes and play a crucial role in host defense against pathogens. Downstream inflammatory responses through inflammasomes are known to be related to the oligomerization degre...
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rhBMP-2-Conjugated Three-Dimensional-Printed Poly(l-lactide) Scaffold is an Effective Bone Substitute
Bone growth factors, particularly bone morphogenic protein-2 (BMP-2), are required for effective treatment of significant bone loss. Despite the extensive development of bone substitutes, much remains to be de...
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Correction to: The splicing factor 1–FLOWERING LOCUS M module spatially regulates temperature-dependent flowering by modulating FLOWERING LOCUS T and LEAFY expression
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Article
Open AccessStepwise molecular mechanisms responsible for chemoresistance in bladder cancer cells
Chemotherapy resistance is an obstacle to cancer therapy and is considered a major cause of recurrence. Thus, understanding the mechanisms of chemoresistance is critical to improving the prognosis of patients....
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First report of cucumber mosaic virus infecting Clematis apiifolia in Korea
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Article
The splicing factor 1–FLOWERING LOCUS M module spatially regulates temperature-dependent flowering by modulating FLOWERING LOCUS T and LEAFY expression
The AtSF1-FLM module spatially controls temperature-dependent flowering by negatively regulating the expression of FT and LFY in the leaf and shoot apex, respectively.
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Article
Fat Graft with Allograft Adipose Matrix and Magnesium Hydroxide-Incorporated PLGA Microspheres for Effective Soft Tissue Reconstruction
Autologous fat grafting is one of the most common procedures used in plastic surgery to correct soft tissue deficiency or depression deformity. However, its clinical outcomes are often suboptimal, and lack of ...
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Article
Open AccessGCRNN: graph convolutional recurrent neural network for compound–protein interaction prediction
Compound–protein interaction prediction is necessary to investigate health regulatory functions and promotes drug discovery. Machine learning is becoming increasingly important in bioinformatics for applicatio...
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Article
Open AccessPrediction of trehalose-metabolic pathway and comparative analysis of KEGG, MetaCyc, and RAST databases based on complete genome of Variovorax sp. PAMC28711
Metabolism including anabolism and catabolism is a prerequisite phenomenon for all living organisms. Anabolism refers to the synthesis of the entire compound needed by a species. Catabolism refers to the break...
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Open AccessNovel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective death of motor neurons. Mutations in Cu, Zn-superoxide dismutase (SOD1) causing the gain of its toxic propert...
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Article
Nysius Plebeius distant (Heteroptera: Lygaeidae; Orsillinae) feeding impacts on seed weight and germination of perilla crop
Nysius species are one of the emerging pests of perilla crop in Korea. Seed weight loss and germination of perilla seeds caused by Nysius plebeius were studied by exposing perilla seeds cv. Deulsaem to six insect...
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Effective detection methods for Pectinatella magnifica Leidy 1851 colony distribution using statoblasts
A rapidly expanding range of Pectinatella magnifica has been reported globally. Although many studies have been conducted to manage this invasive species, surveying methods have mainly been limited to visual obse...
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Effects of Plants on Metacommunities and Correlation Networks of Soil Microbial Groups in an Ecologically Restored Wetland
Plants may influence different aspects of the belowground microorganisms, including abundance, distribution, and interaction, in wetlands. Microbial communities were scrutinized in a 4-year-old restored wetlan...