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  1. Article

    Open Access

    Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1

    Caloric restriction (CR) is known to retard aging and delay functional decline as well as the onset of diseases in most organisms. Ghrelin is secreted from the stomach in response to CR and regulates energy me...

    N Fujitsuka, A Asakawa, A Morinaga, M S Amitani, H Amitani in Molecular Psychiatry (2016)

  2. Article

    Open Access

    Potentiation of ghrelin signaling attenuates cancer anorexiacachexia and prolongs survival

    Cancer anorexia–cachexia syndrome is characterized by decreased food intake, weight loss, muscle tissue wasting and psychological distress, and this syndrome is a major source of increased morbidity and mortal...

    N Fujitsuka, A Asakawa, Y Uezono, K Minami, T Yamaguchi in Translational Psychiatry (2011)