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Article
Open AccessIncreased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1
Caloric restriction (CR) is known to retard aging and delay functional decline as well as the onset of diseases in most organisms. Ghrelin is secreted from the stomach in response to CR and regulates energy me...
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Article
Open AccessPotentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival
Cancer anorexia–cachexia syndrome is characterized by decreased food intake, weight loss, muscle tissue wasting and psychological distress, and this syndrome is a major source of increased morbidity and mortal...