577 Result(s)
within
T. L. **
Internal Medicine
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Article
Optic nerve thickening on high-spatial-resolution MRI predicts early-stage postlaminar optic nerve invasion in retinoblastoma
To assess the diagnostic accuracy of nerve thickening on MRI to predict early-stage postlaminar optic nerve invasion (PLONI) in retinoblastoma. Furthermore, this study aimed to incorporate measurements into a ...
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Ataxia-telangiectasia in Latin America: clinical features, immunodeficiency, and mortality in a multicenter study
Ataxia-telangiectasia (AT) is a rare genetic disorder leading to neurological defects, telangiectasias, and immunodeficiency. We aimed to study the clinical and immunological features of Latin American patient...
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Development of a Protocol for Obtaining a Homologous Cell Product of Animal Origin Intended for Preclinical Studies of Antitumor Vaccine CaTeVac
When develo** a program of preclinical studies of human cell-based drugs intended for adoptive immunotherapy of cancer patients, the biological effect should be substantiated by data describing their immunol...
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Peracute Myocardial Infarction: Features of the Influence of α2-Adrenoreceptor Stimulation on the Isolated Heart
We performed a comparative analysis of the effect of α2-adrenoreceptor stimulation on the performance of Langendorff-isolated heart from rats with experimental myocardial infarction in the acute stage and sham-op...
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Open AccessInter-software and inter-scan variability in measurement of epicardial adipose tissue: a three-way comparison of a research-specific, a freeware and a coronary application software platform
Epicardial adipose tissue (EAT) is a proposed marker of cardiovascular risk; however, clinical application may be limited by variability in post-processing software platforms. We assessed inter-vendor agreemen...
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Features of α2-Adrenergic Regulation of Isolated Rat Heart after Hypokinesia
We studied the effect of the α2-adrenergic receptor agonist clonidine hydrochloride (10—9-10—6 M) on the isolated heart of adult rats after 30-day restriction of motor activity. In hypokinetic rats, in comparison...
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Effect of Adrenoreceptor Stimulation on Peptidergic Regulation of Cardiac Activity in Newborn Rats
We studied the effect of adrenoreceptor stimulation on the frequency of spontaneous activity and amplitude-time parameters of isometric contraction of the atrial myocardial strips from newborn rats, as well as...
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Article
α2C-Adrenergic Receptor Blockade Inhibits Langendorff-Isolated Rat Heart Work
We studied the effect of selective α2C-adrenergic receptor antagonist JP-1302 in concentrations of 10—9-10—6 M on inotropy, chronotropy, and coronary flow in the Langendorff-isolated rat heart. JP-1302 in all stu...
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Mechanisms of Modulation of Adrenergic Regulation of Spontaneous Activity Rate and Atrial Myocardial Contractility in Early Postnatal Ontogeny in Rats
We studied combined effect of the β1,2-adrenoreceptor agonist isoproterenol and the Y1,5 receptor agonist [Leu31, Pro34]neuropeptide Y on the frequency of spontaneous activity and myocardial contractility in 21- ...
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Article
Correction to: Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55
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The Effect of α2-Adrenoreceptors Blockade on the Isolated Rat Heart during the Formation of Sympathetic Innervation
We studied the effects of the α2-adrenergic receptor antagonist yohimbine (10–9-10–6 M) on inotropy, chronotropy, and coronary flow in the Langendorff-isolated heart from 3- and 6-week-old rats. Yohimbine affecte...
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Article
Response of Isolated Rat Heart to α2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period
We studied the effect of α2-adrenoreceptor activation after preliminary If-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α2
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Open AccessThe Effect of Years-Long Exposure to Low-Dose Colchicine on Renal and Liver Function and Blood Creatine Kinase Levels: Safety Insights from the Low-Dose Colchicine 2 (LoDoCo2) Trial
The Low-Dose Colchicine-2 (LoDoCo2) trial showed that 2–4 years exposure to colchicine 0.5 mg once daily reduced the risk of cardiovascular events in patients with chronic coronary artery disease. The potentia...
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Article
Langendorff-Isolated Rat Heart after Acute Experimental Myocardial Infarction
A comparative analysis of functioning of Langendorff-isolated heart from intact rats, sham-operated rats, and rats with a model of myocardial infarction one day after ligation of the left coronary artery was c...
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Article
Open AccessStem cell-based therapy for human diseases
Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSC...
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Delayed Consequences of Experimental Myocardial Infarction: Functional Responses to Stimulation of α2-Adrenoreceptors in the Isolated Heart
We carried out a comparative analysis of the performance of the heart isolated from healthy rats and in 54 and 120 days after modeling of myocardium infarction. On day 120, the blood supply and heart contracti...
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Blockade of α2-Adrenergic Receptors Inhibits Functional Parameters of Langendorff-Isolated Rat Heart
We studied the effect of α2-adrenoreceptor antagonist yohimbine in concentrations of 10—9-10—6 M on the inotropy, chronotropy, and coronary flow of the Langendorff-isolated rat heart. It was found that antagonist...
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Article
Effect of Clonidine Hydrochloride on Isolated Newborn Rat Heart
The concentration dependenies of the chronotropic response and changes in blood supply to the isolated heart of 7-day-old newborn rats induced by application of α2-adrenergic receptor agonist clonidine hydroch...
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Open AccessPatients with preoperative asymptomatic pyuria are not prone to develop febrile urinary tract infection after ureteroscopic lithotripsy
This study aimed to evaluate the association of asymptomatic pyuria before ureterorenoscopic lithotripsy (URSL) with postoperative febrile urinary tract infection (UTI).
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Open AccessEvolution of MET and NRAS gene amplification as acquired resistance mechanisms in EGFR mutant NSCLC
EGFR mutant non-small cell lung cancer patients' disease demonstrates remarkable responses to EGFR-targeted therapy, but inevitably they succumb to acquired resistance, which can be complex and difficult to treat...
