699 Result(s)
within
T. L. **
Biomedicine
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Article
Open AccessGenetic diversity of astroviruses detected in wild aquatic birds in Hong Kong
Wild waterfowl serve as a reservoir of some astroviruses. Fecal samples from wild waterfowl collected at Hong Kong's Marshes were tested using pan-astrovirus reverse transcription-PCR. Positive samples underwe...
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Article
Radiation therapy with phenotypic medicine: towards N-of-1 personalization
In current clinical practice, radiotherapy (RT) is prescribed as a pre-determined total dose divided over daily doses (fractions) given over several weeks. The treatment response is typically assessed months a...
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Article
Ataxia-telangiectasia in Latin America: clinical features, immunodeficiency, and mortality in a multicenter study
Ataxia-telangiectasia (AT) is a rare genetic disorder leading to neurological defects, telangiectasias, and immunodeficiency. We aimed to study the clinical and immunological features of Latin American patient...
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Article
Development of a Protocol for Obtaining a Homologous Cell Product of Animal Origin Intended for Preclinical Studies of Antitumor Vaccine CaTeVac
When develo** a program of preclinical studies of human cell-based drugs intended for adoptive immunotherapy of cancer patients, the biological effect should be substantiated by data describing their immunol...
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Article
An algorithm for electrocardiosignals processing in a multielectrode electrocardiological screening system for visualization of the electrical potential of the epicardium
An algorithm for processing electrocardiosignals in a multielectrode screening system for electrocardiodiagnostics, focused on visualization of the epicardial potential, is proposed. The stages involved in the...
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Article
Peracute Myocardial Infarction: Features of the Influence of α2-Adrenoreceptor Stimulation on the Isolated Heart
We performed a comparative analysis of the effect of α2-adrenoreceptor stimulation on the performance of Langendorff-isolated heart from rats with experimental myocardial infarction in the acute stage and sham-op...
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Article
Features of α2-Adrenergic Regulation of Isolated Rat Heart after Hypokinesia
We studied the effect of the α2-adrenergic receptor agonist clonidine hydrochloride (10—9-10—6 M) on the isolated heart of adult rats after 30-day restriction of motor activity. In hypokinetic rats, in comparison...
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Article
Virtual reality as a countermeasure for astronaut motion sickness during simulated post-flight water landings
Entry motion sickness (EMS) affects crewmembers upon return to Earth following extended adaptation to microgravity. Anticholinergic pharmaceuticals (e.g., Meclizine) are often taken prior to landing; however, ...
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Article
Effect of Adrenoreceptor Stimulation on Peptidergic Regulation of Cardiac Activity in Newborn Rats
We studied the effect of adrenoreceptor stimulation on the frequency of spontaneous activity and amplitude-time parameters of isometric contraction of the atrial myocardial strips from newborn rats, as well as...
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Article
α2C-Adrenergic Receptor Blockade Inhibits Langendorff-Isolated Rat Heart Work
We studied the effect of selective α2C-adrenergic receptor antagonist JP-1302 in concentrations of 10—9-10—6 M on inotropy, chronotropy, and coronary flow in the Langendorff-isolated rat heart. JP-1302 in all stu...
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Article
The Creation and Study of the Mechanism of Action of Compounds of a New Class of Positive Modulators of AMPA-Receptors: Derivatives of 3,7-Diazabicyclo[3.3.1]nonanes
Abstract—This review presents the results of consistent scientific studies of a new class of positive allosteric modulators of AMPA receptors from the class of 3,7-diazabicyclo[3.3.1]nonane derivatives, starting ...
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Article
Mechanisms of Modulation of Adrenergic Regulation of Spontaneous Activity Rate and Atrial Myocardial Contractility in Early Postnatal Ontogeny in Rats
We studied combined effect of the β1,2-adrenoreceptor agonist isoproterenol and the Y1,5 receptor agonist [Leu31, Pro34]neuropeptide Y on the frequency of spontaneous activity and myocardial contractility in 21- ...
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Article
Constructional Features of a Multielectrode Electrocardiology Screening System
The challenges of constructing a noninvasive screening system for electrocardiodiagnostics, focused on visualization of electric potential maps on the surface of the epicardium, is addressed. A functional diag...
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Article
Open AccessAPOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice
The most significant genetic risk factor for develo** late-onset Alzheimer’s disease (AD) is the ε4 allele of apolipoprotein E (APOE4). APOE genotype and biological sex are key modulators of microglial and astr...
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Article
The Effect of α2-Adrenoreceptors Blockade on the Isolated Rat Heart during the Formation of Sympathetic Innervation
We studied the effects of the α2-adrenergic receptor antagonist yohimbine (10–9-10–6 M) on inotropy, chronotropy, and coronary flow in the Langendorff-isolated heart from 3- and 6-week-old rats. Yohimbine affecte...
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Article
Response of Isolated Rat Heart to α2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period
We studied the effect of α2-adrenoreceptor activation after preliminary If-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α2
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Article
Langendorff-Isolated Rat Heart after Acute Experimental Myocardial Infarction
A comparative analysis of functioning of Langendorff-isolated heart from intact rats, sham-operated rats, and rats with a model of myocardial infarction one day after ligation of the left coronary artery was c...
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Article
Delayed Consequences of Experimental Myocardial Infarction: Functional Responses to Stimulation of α2-Adrenoreceptors in the Isolated Heart
We carried out a comparative analysis of the performance of the heart isolated from healthy rats and in 54 and 120 days after modeling of myocardium infarction. On day 120, the blood supply and heart contracti...
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Article
Blockade of α2-Adrenergic Receptors Inhibits Functional Parameters of Langendorff-Isolated Rat Heart
We studied the effect of α2-adrenoreceptor antagonist yohimbine in concentrations of 10—9-10—6 M on the inotropy, chronotropy, and coronary flow of the Langendorff-isolated rat heart. It was found that antagonist...
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Reference Work Entry In depth
Internet Addiction
As Internet addiction is becoming more prevalent around the world, it has attracted considerable scientific and public attention. The present chapter is an updated version of Shek et al. (Internet addiction. I...
