9 Result(s)
within
T G Cooke
Epidemiology
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Article
Open AccessTamoxifen resistance in early breast cancer: statistical modelling of tissue markers to improve risk prediction
For over two decades, the Nottingham Prognostic Index (NPI) has been used in the United Kingdom to calculate risk scores and inform management about breast cancer patients. It is derived using just three clini...
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Article
Open AccessIs the biology of breast cancer changing? A study of hormone receptor status 1984–1986 and 1996–1997
Using archived tumours, those from 1984–1986 and 1996–1997 underwent immunohistochemistry for hormone receptors and grade analysis. A significant shift towards more ER-positive and low-grade disease was found;...
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Article
Open AccessPoor survival outcomes in HER2-positive breast cancer patients with low-grade, node-negative tumours
We present a retrospective analysis on a cohort of low-grade, node-negative patients showing that human epidermal growth factor receptor 2 (HER2) status significantly affects the survival in this otherwise ver...
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Article
Open AccessPhosphorylated c-Src in the nucleus is associated with improved patient outcome in ER-positive breast cancer
Elevated c-Src protein expression has been shown in breast cancer and in vitro evidence suggests a role in endocrine resistance. To investigate whether c-Src is involved in endocrine resistance, we examined the e...
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Article
Open AccessAutomated telephone follow-up after breast cancer: an acceptability and feasibility pilot study
Traditional clinical follow-up after breast cancer is inefficient at detecting relapse and is poorly suited to detecting and ameliorating psychological problems. There is interest in develo** more effective ...
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Article
Open AccessFollow-up in breast cancer: does routine clinical examination improve outcome? A systematic review of the literature
Multiple guidelines exist for the follow-up of breast cancer, with no agreement on frequency or duration. The contribution of routine clinical examination for the detection of potentially treatable relapse, an...
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Article
Open AccessAlternative methods of follow up in breast cancer: a systematic review of the literature
Regular clinical follow up after breast cancer is a common practice. Evidence from retrospective reviews casts doubt on the efficacy of this practice and the various guidelines for follow up show little concor...
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Article
Open AccessDoes deprivation affect breast cancer management?
We evaluated whether social deprivation affected decision-making for breast cancer surgery. Of 3419 patients, 53.6% had mastectomy and this was predicted by deprivation, age, tumour size and hospital, all of w...
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Article
Open AccessA role for BRCA1 in sporadic breast cancer
To test the hypothesis that altered expression of BRCA1 protein may play an important role in sporadic breast cancer development, 50 randomly selected primary breast cancers (frozen sections, 5 years' median f...
