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Article
Multiple chronic lacunes predicting early neurological deterioration and long-term functional outcomes according to TOAST classification in acute ischemic stroke
Studies regarding multiple chronic lacunes (MCLs) and clinical outcome according to stroke etiology are scarce. We sought to evaluate the association between MCL and short-term/long-term clinical outcomes acco...
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Article
A clinical study of 288 patients with anterior cerebral artery infarction
Acute ischemic stroke in the territory of anterior cerebral artery (ACA) is uncommon. Therefore, large population studies evaluating ACA infarction are scarce. We sought to evaluate epidemiological and etiolog...
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Article
Targeted Temperature Management at 36 °C Shows Therapeutic Effectiveness via Alteration of Microglial Activation and Polarization After Ischemic Stroke
Ischemic injury leads to cell death and inflammatory responses after stroke. Microglia especially play a crucial role in this brain inflammation. Targeted temperature management (TTM) at 33 °C has shown neurop...
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Article
Blood-brain barrier permeability assessed by perfusion computed tomography predicts hemorrhagic transformation in acute reperfusion therapy
Hemorrhagic transformation (HT) is one of the most feared complications of acute recanalization therapies. The aim of this study was to evaluate whether blood-brain barrier permeability (BBBP) imaging can pred...
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Article
Open AccessA case report of multiple cervical artery dissection after peripheral type facial palsy and use of steroids
Cervical artery dissection is one of the most important causes of ischemic stroke in young age patients. However, multiple cervical artery dissection simultaneously involving the anterior and posterior circula...
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Article
Open AccessHypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1
Acute ischemic stroke causes significant chronic disability worldwide. We designed this study to clarify the mechanism by which hypothermia helps alleviate acute ischemic stroke. In a middle cerebral artery oc...
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Article
Open AccessTLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity
Recent studies have indicated that Toll-like receptor 4 (TLR4), a pathogen-recognition receptor that triggers inflammatory signals in innate immune cells, is also expressed on sensory neurons, implicating its ...
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Article
Differences in cerebral perfusion according to phenotypes of essential tremor: brain perfusion SPECT study using SPM analysis
Essential tremor (ET) is one of the most common movement disorders. However, few studies regarding the differences of pathophysiology according to phenotypes of ET have been reported. We investigated whether ...
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Article
Orthostatic hypotension, non-dip** and striatal dopamine in Parkinson disease
Orthostatic hypotension and non-dip** are relatively common autonomic dysfunctions in patients with Parkinson disease (PD). These abnormalities have been thought to occur independently of striatal dopaminerg...
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Article
Association between high-sensitivity C-reactive protein and risk of early idiopathic Parkinson’s disease
Although neuroinflammation is known to play an important role in the pathogeneses of neurodegenerative diseases, few studies have been conducted on the association between Parkinson’s disease (PD) and high-sen...
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Article
Diffusion-weighted MR imaging of pyogenic intraventricular empyema
Pyogenic intraventricular empyema (PIE) is a potentially fatal CNS infection. However, it is sometimes difficult to diagnose PIE on the basis of clinical and conventional MRI findings. Diffusion-weighted imagi...