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Article
Open AccessReaction-dependent optical behavior and theoretical perspectives of colloidal ZnSe quantum dots
Colloidal quantum dots (QDs) are attracting research interest because of their unique optical properties that result from the quantum confinement effect. ZnSe QDs, which are II–VI semiconductors, offer a wide ...
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Article
Early onset pancreatic cancer—exploring contemporary treatment and outcomes using real-world data
Pancreatic cancer incidence is increasing in younger populations. Differences between early onset pancreatic cancer (EOPC) and later onset pancreatic cancer (LOPC), and how these should inform management warra...
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Article
Intracranial–intracranial bypass strategies for the treatment of complex intracranial aneurysms: anatomical characteristics and surgical intervention
The effectiveness of revascularization for complex aneurysms is well-established. This study aimed to describe the technical characteristics and clinical efficacy of intracranial-to-intracranial (IC-IC) bypass...
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Article
Open AccessThe LKB1–TSSK1B axis controls YAP phosphorylation to regulate the Hippo–YAP pathway
The Hippo pathway’s main effector, Yes-associated protein (YAP), plays a crucial role in tumorigenesis as a transcriptional coactivator. YAP’s phosphorylation by core upstream components of the Hippo pathway, ...
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Chapter and Conference Paper
B-doped Carbon Quantum Dots Anchored n/n-Junctioned Graphitic Carbon Nitride (g-C3N4) for CO2 Photoreduction
The abundant use of fossil fuel resources, accompanied by climate change and global energy demands, has motivated the search for sustainable transformations of greenhouse gas CO2 into value-added chemical fuels. ...
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Article
Open AccessProtein and lipid expansion microscopy with trypsin and tyramide signal amplification for 3D imaging
Expansion microscopy, whereby the relative positions of biomolecules are physically increased via hydrogel expansion, can be used to reveal ultrafine structures of cells under a conventional microscope. Despit...
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Article
Crystal ribcage: a platform for probing real-time lung function at cellular resolution
Understanding the dynamic pathogenesis and treatment response in pulmonary diseases requires probing the lung at cellular resolution in real time. Despite advances in intravital imaging, optical imaging of the...
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Article
Effects of Ni/Al2O3 catalyst treatment condition on thermocatalytic conversion of spent disposable wipes
Municipal solid waste (MSW) management is an essential municipal service. Proper waste treatment is an important part of the waste management. Thermocatalytic waste upcycling has recently gained great interest...
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Article
Open AccessIterative machine learning-based chemical similarity search to identify novel chemical inhibitors
Machine learning-based chemical screening has made substantial progress in recent years. However, these predictions often have low accuracy and high uncertainty when identifying new active chemical scaffolds. ...
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Article
Open AccessSpeg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads
Here we show that striated muscle preferentially expressed protein kinase α (Spegα) maintains cardiac function in hearts with Spegβ deficiency. Speg is required for stability of excitation-contraction coupling...
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Article
Modification of quebrachitol extracted from natural rubber serum (NRS) to l-chiro-inositol for pharmaceutical and nutraceutical applications
Inositols are a class of biologically active compounds which can be used as precursors for the synthesis of a wide range of bioactive products. Lately, there is growing awareness on the importance of developin...
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Article
Cross-phenotype association analysis of gastric cancer: in-silico functional annotation based on the disease–gene network
A gene or variant has pleiotropic effects, and genetic variant identification across multiple phenotypes can provide a comprehensive understanding of biological pathways shared among different diseases or phen...
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Article
Open AccessEpigenome-wide association study of diabetic chronic kidney disease progression in the Korean population: the KNOW-CKD study
Since the etiology of diabetic chronic kidney disease (CKD) is multifactorial, studies on DNA methylation for kidney function deterioration have rarely been performed despite the need for an epigenetic approac...
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Reference Work Entry In depth
Dyslipidemia in Metabolic Syndrome
Atherogenic dyslipidemia comprises the triad of elevated levels of small dense low-density lipoproteins (sdLDL) and triglycerides, coupled with lowered levels of cardioprotective high-density lipoproteins (HDL...
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Living Reference Work Entry In depth
Dyslipidemia in Metabolic Syndrome
Atherogenic dyslipidemia comprises the triad of elevated levels of small dense low-density lipoproteins (sdLDL) and triglycerides, coupled with lowered levels of cardioprotective high-density lipoproteins (HDL...
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Article
Open AccessBarriers to and facilitators of accessing HIV services for street-involved youth in Canada and Kenya
UNICEF estimates that there are as many as 100 million street-involved youth (SIY) globally. Marginalized conditions put SIY at higher risk of HIV and adverse outcomes once HIV-positive. The objective of this ...
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Article
Open AccessModulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in the SP140 locus have been linked to Crohn’s disease (CD), suggesting a role...
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Article
Open AccessPhase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3
Many synaptic proteins form biological condensates via liquid-liquid phase separation (LLPS). Synaptopathy, a key feature of autism spectrum disorders (ASD), is likely relevant to the impaired phase separation...
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Article
Open AccessMedial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity
The prefrontal cortex is involved in goal-directed behavior. Here, we investigate circuits of the PFC regulating motivation, reinforcement, and its relationship to dopamine neuron activity. Stimulation of medi...
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Article
Application of Solubility and Dissolution Profile Comparison for Prediction of Gastric pH-Mediated Drug-Drug Interactions
The objective of this study was to assess how solubility and dissolution profile comparisons under different pH conditions can be used to predict gastric pH-mediated drug-drug interaction (DDI) potential. We c...
