11 Result(s)
within
Sudhakar Sahoo
English
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Chapter and Conference Paper
Design of a Cyclone-Proofing Humanity Simulator Using Programmable Cellular Automata
In this work, the application of Programmable Cellular Automata (PCA) to model and forecast human survival during cyclones is investigated. Using Moore’s neighbourhood as the primary framework, the study takes...
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Chapter and Conference Paper
A Dynamical Study on Probabilistic Cellular Automata Related to Whale Optimization Algorithm over Time Series Alignment Problems
Alignment of time series of different sampling length are a major topic of research. Many techniques and advance models are formed to tackle the problems. When the alignment is of the multi-objective type, it ...
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Article
Open AccessLong non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung cancer
Lung cancer is the leading cause of cancer-related deaths worldwide. KRAS is the main oncogenic driver in lung cancer that can be activated by gene mutation or amplification, but whether long non-coding RNAs (lnc...
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Chapter and Conference Paper
Analysis of One-Dimensional 4-State Cellular Automata Rules and DNA Evolutions
The main purpose of this research article is to analyse the different mutation rules applied in DNA sequences that are characterized by their State Transition diagrams (STDs) and Space-Time diagrams like Cellu...
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Chapter and Conference Paper
Relationship of Two Discrete Dynamical Models: One-Dimensional Cellular Automata and Integral Value Transformations
Automaton(CA) and an Integral Value Transformation(IVT) are two well established mathematical models which evolve in discrete time steps. Theoretically, studies on CA suggest that CA is capable of pro...
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Article
AMPKα loss promotes KRAS-mediated lung tumorigenesis
AMP-activated protein kinase (AMPK) is a critical sensor of energy status that coordinates cell growth with energy balance. In non-small cell lung cancer (NSCLC) the role of AMPKα is controversial and its cont...
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Article
Open AccessA KRAS-responsive long non-coding RNA controls microRNA processing
Wild-type KRAS (KRASWT) amplification has been shown to be a secondary means of KRAS activation in cancer and associated with poor survival. Nevertheless, the precise role of KRASWT overexpression in lung cancer ...
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Article
Open AccessAnalysis of circulating cell-free DNA identifies KRAS copy number gain and mutation as a novel prognostic marker in Pancreatic cancer
Serial biopsy of pancreatic ductal adenocarcinoma (PDAC), to chart tumour evolution presents a significant challenge. We examined the utility of circulating free DNA (cfDNA) as a minimally invasive approach ac...
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Article
Open AccessSignaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin
Precision medicine aims to tailor cancer therapies to target specific tumor-promoting aberrations. For tumors that lack actionable drivers, which occurs frequently in the clinic, extensive molecular characteri...
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Article
Open AccessKRAS induces lung tumorigenesis through microRNAs modulation
Oncogenic KRAS induces tumor onset and development by modulating gene expression via different molecular mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs that have been established as main players in tumo...
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Article
Open AccessPDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways
In NSCLC alterations in PDGF receptors are markers of worst prognosis and efficient targeting of these receptors is yet to be achieved. In this study, we explored PDGFR-regulated microRNAs demonstrating that m...
