7 Result(s)
within
Stuart Horswell
Life Sciences
English
-
Article
Author Correction: Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization
-
Article
Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization
Radiotherapy is one of the most effective approaches to achieve tumor control in cancer patients, although healthy tissue injury due to off-target radiation exposure can occur. In this study, we used a model o...
-
Article
Open AccessSpatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study
Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically relevant clonal dynamics remain limited. We investigated spatial and temporal features of clonal diversification i...
-
Article
Selection of metastasis competent subclones in the tumour interior
The genetic evolutionary features of solid tumour growth are becoming increasingly well described, but the spatial and physical nature of subclonal growth remains unclear. Here, we utilize 102 macroscopic whol...
-
Article
Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability
Rewiring of cellular programmes in malignant cells generates cancer-specific vulnerabilities. Here, using an unbiased screening strategy aimed at identifying non-essential genes required by tumour cells to sus...
-
Article
Open AccessDeciphering clonality in aneuploid breast tumors using SNP array and sequencing data
Intra-tumor heterogeneity concerns the existence of genetically different subclones within the same tumor. Single sample quantification of heterogeneity relies on precise determination of chromosomal copy numb...
-
Article
Open AccessDevelopment of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution
Genomic analysis of multi-focal renal cell carcinomas from an individual with a germline VHL mutation offers a unique opportunity to study tumor evolution.
