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Article
Open AccessHigh-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
Compatibility for human leukocyte antigen (HLA) genes between transplant donors and recipients improves graft survival but prospective matching is rarely performed due to the vast heterogeneity of this gene co...
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Article
Presence of donor-encoded centromeric KIR B content increases the risk of infectious mortality in recipients of myeloablative, T-cell deplete, HLA-matched HCT to treat AML
The reported influence of donor Killer-cell Immunoglobulin-like Receptor (KIR) genes on the outcomes of haematopoietic cell transplantation (HCT) are contradictory, in part due to diversity of disease, donor s...
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Article
Open AccessThe IPD Project: a centralised resource for the study of polymorphism in genes of the immune system
The Immuno Polymorphism Database (IPD), https://www.ebi.ac.uk/ipd/, is a set of specialist databases that enable the study of polymorphic genes which function as part of the vertebrate immune system. The major...
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Article
Correction to: Nomenclature report 2019: major histocompatibility complex genes and alleles of great and small ape and old and new world monkey species
The original version of this article contained a spelling error in the Acknowledgments regarding the name of the funding organisation supporting GM and JAH. UKRI-BBSCR should have been UKRI-BBSRC, as is now in...
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Article
Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species
The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are high gene density, gene copy number variation, and allelic ...
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Article
Nomenclature report for killer-cell immunoglobulin-like receptors (KIR) in macaque species: new genes/alleles, renaming recombinant entities and IPD-NHKIR updates
The Killer-cell Immunoglobulin-like Receptors (KIR) are encoded by a diverse group of genes, which are characterized by allelic polymorphism, gene duplications, and recombinations, which may generate recombina...
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Article
Trophoblast organoids as a model for maternal–fetal interactions during human placentation
The placenta is the extraembryonic organ that supports the fetus during intrauterine life. Although placental dysfunction results in major disorders of pregnancy with immediate and lifelong consequences for th...
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Article
Open AccessIPD-MHC: nomenclature requirements for the non-human major histocompatibility complex in the next-generation sequencing era
The IPD-MHC Database is the official repository for non-human MHC sequences, overseen and supported by the Comparative MHC Nomenclature Committee, providing access to curated MHC data and associated analysis t...
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Article
Comparative MHC nomenclature: report from the ISAG/IUIS-VIC committee 2018
Significant progress has been made over the last decade in defining major histocompatibility complex (MHC) diversity at the nucleotide, allele, haplotype, diplotype, and population levels in many non-human spe...
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Article
Open AccessNomenclature for the KIR of non-human species
The increasing number of Killer Immunoglobulin-like Receptor (KIR) sequences available for non-human primate species and cattle has prompted development of a centralized database, guidelines for a standardized...
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Protocol
The IPD Databases: Cataloguing and Understanding Allele Variants
The IMGT/HLA Database has provided a repository for information regarding polymorphism in the genes of the immune system since 1998. In 2003, it was absorbed into the Immuno Polymorphism Database (IPD). The IP...
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Article
Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium
In humans, the endometrium, the uterine mucosal lining, undergoes dynamic changes throughout the menstrual cycle and pregnancy. Despite the importance of the endometrium as the site of implantation and nutriti...
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Article
Open AccessA donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological conditions. Acute graft-versus-host disease (aGVHD) is a prevalent immune-mediated complication followin...
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Protocol
IMGT/HLA and the Immuno Polymorphism Database
The IMGT/HLA Database (http://www.ebi.ac.uk/ipd/imgt/hla/) was first released over 15 years ago, providing the HLA community with a searchable repository of highly...
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Protocol
Natural Killer Cells and Killer-Cell Immunoglobulin-Like Receptor Polymorphisms: Their Role in Hematopoietic Stem Cell Transplantation
Natural killer (NK) cells are important effector cells in the early control of infected, malignant, and “nonself” cells. Various receptor families are involved in enabling NK cells to detect and efficiently el...
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Article
Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species
The major histocompatibility complex (MHC) plays a central role in the adaptive immune response. The MHC region is characterised by a high gene density, and most of these genes display considerable polymorphis...
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Article
Cattle MHC nomenclature: is it possible to assign sequences to discrete class I genes?
The cattle major histocompatibility complex (MHC) region contains a variable number of classical class I genes encoding polymorphic molecules involved in antigen presentation. Six classical class I genes have ...
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Article
Short template amplicon and multiplex megaprimer-enabled relay (STAMMER) sequencing, a simultaneous approach to higher throughput sequence-based ty** of polymorphic genes
Sequence-based ty** (SBT) is a powerful method of genoty** in highly polymorphic gene systems. In standard SBT methods, both strands of a double-stranded template amplicon are sequenced in separate reactio...
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Chapter
The IMGT/HLA Database
It is almost 10 years since the IMGT/HLA Database was released providing the HLA community with a searchable repository of highly curated sequences. The HLA complex is located within the 6p21.3 region on the s...
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Chapter
The Immuno Polymorphism Database
The Immuno Polymorphism Database (IPD) (http://www.ebi.ac.uk/ipd/) is a set of specialist databases developed for the study of polymorphic genes of the immune syst...
