14 Result(s)
within
Stephen R. Piccolo
Biomedicine
English
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Article
Open AccessEvaluation of the upregulation and surface expression of hypoxanthine guanine phosphoribosyltransferase in acute lymphoblastic leukemia and Burkitt’s B cell lymphoma
The aim of this study is to determine whether Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) could be used as a biomarker for the diagnosis and treatment of B cell malignancies. With 4.3% of all new can...
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Publisher Correction: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
In the version of this article originally published, the color key in Fig. 1a was wrong. In the Cytogenetics key, the box over t(8;21) originally was green. It should have been red, matching the color of the s...
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Open AccessCorrection to: Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies
Following publication of the original article [1], the authors would like to make an amendment to the Acknowledgements section.
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Open AccessPotential new biomarkers for endometrial cancer
Incidence of endometrial cancer are rising both in the United States and worldwide. As endometrial cancer becomes more prominent, the need to develop and characterize biomarkers for early stage diagnosis and t...
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Open AccessMembrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies
Lung, breast, and colorectal malignancies are the leading cause of cancer-related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite efforts to improve prevention methods, early...
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Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
Nat. Med.; 10.1038/nm.4439; corrected online 1 January 2018 In the version of this article initially published online, Figure 1a has two black boxes in the key that are labeled as 'Unknown'; these boxes should...
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The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
A comprehensive molecular analysis of almost 1,000 pediatric subjects with acute myeloid leukemia (AML) uncovers widespread differences in pediatric AML as compared to adult AML, including a higher frequency o...
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Open AccessClassifying cancer genome aberrations by their mutually exclusive effects on transcription
Malignant tumors are typically caused by a conglomeration of genomic aberrations—including point mutations, small insertions, small deletions, and large copy-number variations. In some cases, specific chemothe...
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Open AccessActivity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes
The growth factor receptor network (GFRN) plays a significant role in driving key oncogenic processes. However, assessment of global GFRN activity is challenging due to complex crosstalk among GFRN components,...
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Open AccessGene-expression patterns in peripheral blood classify familial breast cancer susceptibility
Women with a family history of breast cancer face considerable uncertainty about whether to pursue standard screening, intensive screening, or prophylactic surgery. Accurate and individualized risk-estimation ...
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Open AccessInferring pathway dysregulation in cancers from multiple types of omic data
Although in some cases individual genomic aberrations may drive disease development in isolation, a complex interplay among multiple aberrations is common. Accordingly, we developed Gene Set Omic Analysis (GSO...
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Robust meta-analysis shows that glioma transcriptional subty** complements traditional approaches
Gliomas traditionally have been sub-classified based on histopathological observations. However, this approach is subject to inter-observer variability, and histopathological features may not reflect the biolo...
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Open AccessGenomic pathway analysis reveals that EZH2 and HDAC4 represent mutually exclusive epigenetic pathways across human cancers
Alterations in epigenetic marks, including methylation or acetylation, are common in human cancers. For many epigenetic pathways, however, direct measures of activity are unknown, making their role in various ...
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Open AccessMultiplicity: an organizing principle for cancers and somatic mutations
With the advent of whole-genome analysis for profiling tumor tissue, a pressing need has emerged for principled methods of organizing the large amounts of resulting genomic information. We propose the concept ...
