3 Result(s)
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Stephan Schilling
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessHelical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor
The zinc-dependent metalloprotease meprin α is predominantly expressed in the brush border membrane of proximal tubules in the kidney and enterocytes in the small intestine and colon. In normal tissue homeosta...
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Article
Open AccessDevelopment of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer’s disease with reduced complement activation
In clinical trials with early Alzheimer’s patients, administration of anti-amyloid antibodies reduced amyloid deposits, suggesting that immunotherapies may be promising disease-modifying interventions against ...
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Article
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
It is shown that the formation of amyloid-β oligomers, one of the histopathological signatures of Alzheimer’s disease, can be triggered by small quantities of a specifically truncated and post-translationally ...
