13 Result(s)

Article

Hybrid speciation driven by multilocus introgression of ecological traits

Hybridization allows adaptations to be shared among lineages and may trigger the evolution of new species^1,2. However, convincing examples of homoploid hybrid speciation remain rare because it is challenging to d...

Neil Rosser, Fernando Seixas, Lucie M. Queste, Bruna Cama, Ronald Mori-Pezo… in Nature (2024)

Article

Reply to: How carvedilol does not activate β₂-adrenoceptors

Evi Kostenis, Jesus Gomeza, Elke Miess-Tanneberg… in Nature Communications (2023)

Article

Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach

Somatostatin receptors are clinically validated GPCR biomarkers for diagnosis and treatment of various neuroendocrine tumors (NET). Among the five somatostatin receptors, SST2 and SST3 are associated with apop...

Mor Oron-Herman, David Kirmayer, Amelie Lupp, Stefan Schulz… in Scientific Reports (2023)

Article

Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues

Little is known about the expression of the orphan G protein-coupled receptor GPR19 at the protein level. Therefore, we developed a rabbit antibody, targeting human GPR19. After verification of the antibody sp...

Lorena Gerlach, Anna-Sophia Liselott Beyer, Daniel Kaemmerer… in Scientific Reports (2023)

Article

How Carvedilol activates β₂-adrenoceptors

Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are still unclear. Beyond bl...

Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo… in Nature Communications (2022)

Article

Reassessment of somatostatin receptor SST4 expression in bronchopulmonary and gastroenteropancreatic neuroendocrine neoplasms using the novel rabbit monoclonal anti-human SST4 antibody 7H49L61

Somatostatin receptors SST1, SST2, and SST5 are overexpressed in neuroendocrine neoplasms (NENs), but little is known about SST4 expression in NENs because of a lack of specific monoclonal antibodies. We recen...

Blanca Ehms, Daniel Kaemmerer, Jörg Sänger, Stefan Schulz… in Scientific Reports (2022)

Article

Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics

Multi-receptor targeting has been proposed as a promising strategy for the development of opioid analgesics with fewer side effects. Cebranopadol and AT-121 are prototypical bifunctional ligands targeting the ...

Pooja Dasgupta, Anika Mann, Willma E. Polgar, Rainer K. Reinscheid… in Scientific Reports (2022)

Article

New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D₂ receptor regulation and signaling

The dopamine D₂ receptor (D₂R) is the target of drugs used to treat the symptoms of Parkinson’s disease and schizophrenia. The D₂R is regulated through its interaction with and phosphorylation by G protein recept...

Anika Mann, Alastair C. Keen, Hanka Mark, Pooja Dasgupta… in Scientific Reports (2021)

Article

Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies

The δ-opioid receptor (DOP) is an attractive pharmacological target due to its potent analgesic, anxiolytic and anti-depressant activity in chronic pain models. However, some but not all selective DOP agonists...

Anika Mann, Sophia Liebetrau, Marie Klima, Pooja Dasgupta… in Scientific Reports (2020)

Article

Ge_1−xSn_x alloys: Consequences of band mixing effects for the evolution of the band gap Γ-character with Sn concentration

In this work we study the nature of the band gap in GeSn alloys for use in silicon-based lasers. Special attention is paid to Sn-induced band mixing effects. We demonstrate from both experiment and ab-initio t...

Timothy D. Eales, Igor P. Marko, Stefan Schulz, Edmond O’Halloran… in Scientific Reports (2019)

Article

Different somatostatin and CXCR4 chemokine receptor expression in gastroenteropancreatic neuroendocrine neoplasms depending on their origin

Somatostatin receptors (SST), especially SST2A, are known for their overexpression in well-differentiated gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). The chemokine receptor CXCR4, in contrast, i...

Rebekka Mai, Daniel Kaemmerer, Tina Träger, Elisa Neubauer… in Scientific Reports (2019)

Article

Deterministic optical polarisation in nitride quantum dots at thermoelectrically cooled temperatures

We report the successful realisation of intrinsic optical polarisation control by growth, in solid-state quantum dots in the thermoelectrically cooled temperature regime (≥200 K), using a non-polar InGaN syste...

Tong Wang, Tim J. Puchtler, Saroj K. Patra, Tongtong Zhu… in Scientific Reports (2017)

Article

Chemical recognition of fruit ripeness in spider monkeys (Ateles geoffroyi)

Primates are now known to possess well-developed olfactory sensitivity and discrimination capacities that can play a substantial role in many aspects of their interaction with conspecifics and the environment....

Omer Nevo, Rosa Orts Garri, Laura Teresa Hernandez Salazar… in Scientific Reports (2015)