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  1. No Access

    Chapter

    Pattern Recognition by Toll-like Receptors

    The mammalian immune system senses pathogens through pattern recognition receptors and responds with activation. The Toll-like receptors (TLRs) that are expressed on antigen presenting cells such as macrophage...

    Stefan Bauer, Thomas Müller, Svetlana Hamm in Target Pattern Recognition in Innate Immunity (2009)

  2. No Access

    Chapter

    TLR9-Mediated Recognition of DNA

    The mammalian immune system senses pathogens through pattern recognition receptors (PRRs) and responds with activation. The Toll-like receptor (TLR) family that consists of 13 receptors plays a critical role i...

    Thomas Müller, Svetlana Hamm… in Toll-Like Receptors (TLRs) and Innate Immunity (2008)

  3. No Access

    Article

    Toll-erating self DNA

    Discrimination between self and bacterial DNA has been attributed in part to differential modification of prokaryotic and eukaryotic DNA. However, cellular localization of innate DNA receptors may be even more...

    Stefan Bauer in Nature Immunology (2006)

  4. Article

    Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

    Marion Jurk, Florian Heil, Jörg Vollmer, Christian Schetter… in Nature Immunology (2002)

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    Article

    Crystal structure of the murine NK cell–activating receptor NKG2D at 1.95 Å

    NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory molecule that is found on natural killer cells, T cells and activated macrophages. The natural ligands for murine NKG2D are distant major hist...

    Dennis W. Wolan, Luc Teyton, Markus G. Rudolph, Brigitte Villmow… in Nature Immunology (2001)

  6. No Access

    Article

    Role of perforin, granzymes and the proliferative state of the target cells in apoptosis and necrosis mediated by bispecific-antibody-activated cytotoxic T cells

     Bispecific monoclonal antibodies (bi-mAb), directed against a tumor-associated antigen and the CD3 or CD28 antigen on T lymphocytes, induce activation of resting T lymphocytes and target-specific tumor cell l...

    C. Renner, Gerhard Held, Sascha Ohnesorge, Stefan Bauer… in Cancer Immunology, Immunotherapy (1997)

  7. No Access

    Article

    HLA-A2-restricted peripheral blood cytolytic T lymphocyte response to HPV type 16 proteins E6 and E7 from patients with neoplastic cervical lesions

     The DNA from human papillomavirus (HPV) can be detected in 90% of cervical carcinomas. To address whether patients infected with HPV can mount efficient T cell responses to this pathogen we examined the cytot...

    Carys Evans, Stefan Bauer, Thomas Grubert… in Cancer Immunology, Immunotherapy (1996)