Skip to main content

2 Result(s)

within Spinel Karas Remove this filter

and

  1. No Access

    Article

    Integration of DNA sequencing with population pharmacokinetics to improve the prediction of irinotecan exposure in cancer patients

    Irinotecan (CPT-11) is an anticancer agent widely used to treat adult solid tumours. Large interindividual variability in the clearance of irinotecan and SN-38, its active and toxic metabolite, results in high...

    Spinel Karas, Amy S. Etheridge, Deborah A. Nickerson… in British Journal of Cancer (2022)

  2. No Access

    Article

    Optimal Sampling Strategies for Irinotecan (CPT-11) and its Active Metabolite (SN-38) in Cancer Patients

    Irinotecan (CPT-11) is an anticancer agent widely used in the treatment of a variety of adult solid tumors. The objective of this study was to develop an optimal sampling strategy model that accurately estimat...

    Spinel Karas, Amy S. Etheridge, Eleftheria Tsakalozou… in The AAPS Journal (2020)