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  1. Article

    Open Access

    Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming

    T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are...

    Hao Wu, **ufeng Zhao, Sophia M. Hochrein, Miriam Eckstein… in Nature Communications (2023)

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