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    Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases

    A series of analogs of vegfrecine, a natural quinone vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor, was synthesized via oxidative amination of 2,5-dihydroxybenzamide with functi...

    Hayamitsu Adachi, Chisato Nosaka, Sonoko Atsumi, Koichi Nakae in The Journal of Antibiotics (2021)

  2. Article

    Correction: Corrigendum: Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology

    Correction to: The Journal of Antibiotics (2018) 71, 60–71; doi:10.1038/ja.2017.138; published online 1 November 2017 The authors of the above article noticed the following errors in the publication. In the In...

    Hayamitsu Adachi, Koichi Nakae, Shuichi Sakamoto in The Journal of Antibiotics (2018)

  3. Article

    Novel approaches for identification of anti-tumor drugs and new bioactive compounds

    Thanks to the pioneering work done by Professor Hamao Umezawa, bioactive compounds have been used in treatment of several diseases including cancer. In this review, we discuss our work, which focuses on develo...

    Manabu Kawada, Sonoko Atsumi, Shun-ichi Wada in The Journal of Antibiotics (2018)

  4. Article

    Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology

    Microbial metabolites have attracted increasing interest as a source of therapeutics and as probes for biological mechanisms. New microbial metabolites and derivatives targeted at inflammation and bone disease...

    Hayamitsu Adachi, Koichi Nakae, Shuichi Sakamoto in The Journal of Antibiotics (2018)