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Article

Munc13 C₂B domain is an activity-dependent Ca²⁺ regulator of synaptic exocytosis

Munc13 primes synaptic vesicles for exocytosis. Studies now reveal that the central C2B domain of Munc13 contains a structurally unusual Ca²⁺ binding site that confers specific phospholipid-binding properties to ...

Ok-Ho Shin, Jun Lu, Jeong-Seop Rhee… in Nature Structural & Molecular Biology (2010)