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Tumor-associated macrophage-secreted 14-3-3ζ signals via AXL to promote pancreatic cancer chemoresistance

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  1. Article

    Open Access

    Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy

    Previous studies by our group have shown that oxidative phosphorylation (OXPHOS) is the main pathway by which pancreatic cancer stem cells (CSCs) meet their energetic requirements; therefore, OXPHOS represents...

    Sonia Alcalá, Lara Villarino… in Journal of Experimental & Clinical Cancer … (2024)

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  2. Article

    Open Access

    Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug

    Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is emerging as both a novel cancer hallm...

    Emilia Alors-Perez, Ricardo Blázquez-Encinas… in Journal of Experimental & Clinical Cancer … (2021)

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