4 Result(s)
within
Songyi Park
Biomedicine
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Article
Open AccessLong-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model
Age-related changes in the cerebrovasculature, including blood–brain barrier (BBB) disruption and vascular dementia, are emerging as potential risks for many neurodegenerative diseases. Therefore, the endothel...
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Article
Open AccessMutations of TP53 and genes related to homologous recombination repair in breast cancer with germline BRCA1/2 mutations
Germline mutations of breast cancer susceptibility gene BRCA1 and BRCA2 (gBRCA1/2) are associated with elevated risk of breast cancer in young women in Asia. BRCA1 and BRCA2 proteins contribute to genomic stabili...
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Article
Open AccessCU06-1004 (endothelial dysfunction blocker) ameliorates astrocyte end-feet swelling by stabilizing endothelial cell junctions in cerebral ischemia/reperfusion injury
Cerebral ischemia, or stroke, is widespread leading cause of death and disability. Surgical and pharmacological interventions that recover blood flow are the most effective treatment strategies for stroke pati...
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Article
Open AccessMicroRNA-148a/b-3p regulates angiogenesis by targeting neuropilin-1 in endothelial cells
MicroRNAs (miRs) are crucial regulators of vascular endothelial cell (EC) functions, including migration, proliferation, and survival. However, the role of most miRs in ECs remains unknown. Using RNA sequencin...
