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  1. Article

    Open Access

    Disease-specific tau filaments assemble via polymorphic intermediates

    Intermediate species in the assembly of amyloid filaments are believed to play a central role in neurodegenerative diseases and may constitute important targets for therapeutic intervention1,2. However, structura...

    Sofia Lövestam, David Li, Jane L. Wagstaff, Abhay Kotecha, Dari Kimanius… in Nature (2024)

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  2. Article

    Open Access

    Age-dependent formation of TMEM106B amyloid filaments in human brains

    Many age-dependent neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β, α-synuc...

    Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang… in Nature (2022)

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